Xanthone Derivatives in the Fight against Glioblastoma and Other Cancers

Xanthone derivatives constitute an interesting and widely studied group of compounds, both in terms of the activity of naturally occurring plant ingredients and as a scaffold with high biological activity potential for medicinal chemists. This group of compounds has already been the subject of revie...

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Published inApplied sciences Vol. 13; no. 5; p. 2897
Main Authors Mazur, Gabriela, Pańczyk-Straszak, Katarzyna, Waszkielewicz, Anna Maria
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 01.02.2023
Subjects
anticancer
Apoptosis
Brain cancer
Brain research
Breast cancer
Cancer
Cancer therapies
central nervous system
Chemotherapy
Clinical trials
Cytotoxicity
Dehydrogenases
Epidermal growth factor
glioblastoma
Nervous system
Proteins
Radiation therapy
Tumors
viability assays
xanthone derivatives
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Summary:Xanthone derivatives constitute an interesting and widely studied group of compounds, both in terms of the activity of naturally occurring plant ingredients and as a scaffold with high biological activity potential for medicinal chemists. This group of compounds has already been the subject of reviews. However, our purpose was to prepare a publication for medicinal chemists to have a clear overview of anticancer activity, particularly in central nervous system cancer glioblastoma, and to be able to compare their new achievements to the anticancer activity that has already been found in this group. An integral part of the work is a tabular summary of the literature results of antineoplastic activity (e.g., IC50 values) for xanthone derivatives in various types of in vitro viability assays.
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ISSN:2076-3417
2076-3417
DOI:10.3390/app13052897