Effect of beta-agonists on production of cytokines by activated T cells obtained from asthmatic patients and normal subjects

Intracellular levels of cAMP were found to regulate T cell activity. We examined whether beta2-agonists altered cytokine production and cyclic adenosine monophosphate (cAMP) accumulation in concanavalin A (ConA)-activated peripheral T cells from asthmatic patients. Procaterol and isoproterenol weakl...

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Bibliographic Details
Published inThe Journal of asthma Vol. 36; no. 7; p. 619
Main Authors Aihara, M, Dobashi, K, Horie, T, Araki, T, Yoshii, A, Iizuka, K, Nakazawa, T, Mori, M
Format Journal Article
LanguageEnglish
Published England 01.01.1999
Subjects
Adrenergic beta-Agonists - pharmacology
Asthma - metabolism
Cells, Cultured
Concanavalin A - pharmacology
Cyclic AMP - metabolism
Humans
Interleukin-2 - biosynthesis
Interleukin-4 - biosynthesis
Interleukin-5 - biosynthesis
Interleukins - biosynthesis
Isoproterenol - pharmacology
Lymphocyte Activation
Procaterol - pharmacology
T-Lymphocytes - metabolism
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ISSN0277-0903
DOI10.3109/02770909909087300

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Summary:Intracellular levels of cAMP were found to regulate T cell activity. We examined whether beta2-agonists altered cytokine production and cyclic adenosine monophosphate (cAMP) accumulation in concanavalin A (ConA)-activated peripheral T cells from asthmatic patients. Procaterol and isoproterenol weakly decreased the ConA-elicited interleukin (IL)-4 and IL-5 secretion; however, the inhibitory effect of procaterol on the ConA-induced IL-2 secretion was inferior to that of isoproterenol in normal controls and was little in asthmatics. The intracellular accumulation of cAMP by procaterol was not altered compared with that by isoproterenol. Results suggest that there is a qualitative difference between procaterol- and isoproterenol-induced cAMP accumulation in T cells.
ISSN:0277-0903
DOI:10.3109/02770909909087300