Human microsomal prostaglandin E synthase 1: a member of the MAPEG protein superfamily

In this chapter, we briefly review the MAPEG superfamily (membrane associated proteins in eicosanoid and glutathione metabolism), a family of proteins in which all human members except one possess glutathione conjugating capacity. Recent findings regarding the biological functions of MAPEG proteins...

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Bibliographic Details
Published inMethods in enzymology Vol. 401; p. 147
Main Authors Pettersson, Pär L, Thorén, Staffan, Jakobsson, Per-Johan
Format Journal Article
LanguageEnglish
Published United States 2005
Subjects
Glutathione - metabolism
Humans
Intramolecular Oxidoreductases - chemistry
Intramolecular Oxidoreductases - genetics
Intramolecular Oxidoreductases - metabolism
Isoenzymes - chemistry
Isoenzymes - genetics
Isoenzymes - metabolism
Microsomes - enzymology
Molecular Structure
Multigene Family
Prostaglandin-E Synthases
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Summary:In this chapter, we briefly review the MAPEG superfamily (membrane associated proteins in eicosanoid and glutathione metabolism), a family of proteins in which all human members except one possess glutathione conjugating capacity. Recent findings regarding the biological functions of MAPEG proteins are highlighted. More extensively, the characterization of human microsomal prostaglandin E synthase 1 is presented, including results and applied methodology.
ISSN:0076-6879
DOI:10.1016/s0076-6879(05)01009-8