Determination of (+)-3,3′,5,5′-Tetraiodo-L-thyronine (L-T4) in Serum and Pharmaceutical Formulations using a Sequential Injection Analysis/Immunosensor System

A sequential injection analysis/immunosensor system is proposed for the analysis of thyroxine (L-T 4 ) in serum and in pharmaceutical formulations with a rate of 75 samples/hour. The immunosensor design is based on the physical immobilization of anti-L-T 4 in carbon paste. The working concentration...

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Bibliographic Details
Published inJournal of immunoassay & immunochemistry Vol. 29; no. 4; pp. 348 - 355
Main Authors Staden, Raluca-Ioana Stefan-van, Staden, Jacobus Frederick van, Aboul-Enein, Hassan Y., Mirica, Marius Constantin, Balcu, Ionel, Mirica, Nicolae
Format Journal Article
LanguageEnglish
Published England Taylor & Francis Group 01.01.2008
Subjects
Amperometric immunosensor
Antibodies, Monoclonal - immunology
Biosensing Techniques
Flow Injection Analysis - methods
Humans
Immunoassay
L-T
Pharmaceutical Preparations - analysis
Sequential injection analysis
Thyroid hormone
Thyroxine - analysis
Thyroxine - blood
Thyroxine - immunology
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Summary:A sequential injection analysis/immunosensor system is proposed for the analysis of thyroxine (L-T 4 ) in serum and in pharmaceutical formulations with a rate of 75 samples/hour. The immunosensor design is based on the physical immobilization of anti-L-T 4 in carbon paste. The working concentration range of the immunosensor in the sequential injection analysis system is between 36 and 1080 ng/mL with a limit of detection of 24.6 ng/mL. The system is very reliable and very easy to design and operate.
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ISSN:1532-1819
1532-4230
DOI:10.1080/15321810802329690