Influence of vitamin D on liver fibrosis in chronic hepatitis C: A systematic review and meta-analysis of the pooled clinical trials data

AIM To investigate the relationship between vitamin D and liver fibrosis in hepatitis C-monoinfected or hepatitis C virus(HCV)-human immunodeficiency virus(HIV) coinfected patients. METHODS Pertinent studies were located by a library literature search in PubM ed/Embase/Cochrane/Scopus/LILACS by two...

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Published inWorld journal of hepatology Vol. 9; no. 5; pp. 278 - 287
Main Authors Dadabhai, Alia S, Saberi, Behnam, Lobner, Katie, Shinohara, Russell T, Mullin, Gerard E
Format Journal Article
LanguageEnglish
Published United States Baishideng Publishing Group Inc 18.02.2017
Subjects
Systematic Reviews
Chronic hepatitis C
Liver fibrosis
Vitamin D
Hepatitis C virus
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Summary:AIM To investigate the relationship between vitamin D and liver fibrosis in hepatitis C-monoinfected or hepatitis C virus(HCV)-human immunodeficiency virus(HIV) coinfected patients. METHODS Pertinent studies were located by a library literature search in PubM ed/Embase/Cochrane/Scopus/LILACS by two individual reviewers. Inclusion criteria:(1) studies with patients with HCV or co-infected HCV/HIV;(2) studies with patients ≥ 18 years old;(3) studies that evaluated liver fibrosis stage, only based on liver biopsy; and(4) studies that reported serum or plasma 25(OH)D levels. Studies that included pediatric patients, other etiologies of liver disease, or did not use liver biopsy for fibrosis evaluation, or studies with inadequate data were excluded. Estimated measures of association reported in the literature, as well as corresponding measures of uncertainty, were recorded and corresponding odds ratios with 95%CI were included in a meta-analysis. RESULTS The pooled data of this systematic review showed that 9 of the 12 studies correlated advanced liver disease defined as a Metavir value of F3/4 with 25(OH) D level insufficiency. The meta-analysis indicated a significant association across studies.CONCLUSION Low vitamin D status is common in chronic Hepatitis C patients and is associated with advanced liver fibrosis.
Bibliography:Alia S Dadabhai;Behnam Saberi;Katie Lobner;Russell T Shinohara;Gerard E Mullin;Division of Gastroenterology and Hepatology, the Johns Hopkins University School of Medicine;Department of Biostatistics and Epide-miology, Perelman School of Medicine, University of Pennsylvania
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Author contributions: Dadabhai AS, Saberi B and Mullin GE contributed equally to the data evaluation, manuscript preparation, editing, figures, and final submission; Shinohara RT provided biostatistics methodology oversight, data extractions and meta-analysis with pooled data figure preparation and manuscript preparation and editing; Lobner K provided informatics methodology support, conducted the literature search, and reviewed and edited the manuscript.
Correspondence to: Alia S Dadabhai, MD, Assistant Professor, Division of Gastroenterology and Hepatology, the Johns Hopkins University School of Medicine, 4940 Eastern Ave A504, Baltimore, MD 21224, United States. adadabh1@jhmi.edu
Telephone: +1-410-5507857 Fax: +1-410-5507861
ISSN:1948-5182
1948-5182
DOI:10.4254/wjh.v9.i5.278