Dynamic Correlation between Platelet Aggregation and Inflammatory-like State in Athlete Horses

This study aimed to assess the effect of exercise on serum electrophoretic protein pattern, C-reactive protein (CRP) and platelet aggregation in horses subjected to a jumping exercise. The possible relationship between acute-phase reactions and platelet reactivity in the context of exercise was inve...

Full description

Saved in:
Bibliographic Details
Published inApplied sciences Vol. 14; no. 5; p. 2086
Main Authors Arfuso, Francesca, Rizzo, Maria, Arrigo, Federica, Faggio, Caterina, Giudice, Elisabetta, Piccione, Giuseppe, Giannetto, Claudia
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 01.03.2024
Subjects
acute-phase proteins
Albumin
Animal training
athletic horse
Automation
Blood platelets
Blood proteins
C-reactive protein
Cytokines
Exercise
Homeostasis
Horses
Inflammation
platelet aggregation
Proteins
Regression analysis
serum protein electrophoresis
Software
United States > US
Italy
Japan
Online AccessGet full text

Cover

More Information
Summary:This study aimed to assess the effect of exercise on serum electrophoretic protein pattern, C-reactive protein (CRP) and platelet aggregation in horses subjected to a jumping exercise. The possible relationship between acute-phase reactions and platelet reactivity in the context of exercise was investigated. Blood samples were collected from 10 jumper horses at rest (TREST), within 5 min from the end of exercise (TPE5), and 30 min (TPE30) and 60 min after exercise (TPE60). The serum values of total proteins; CRP; albumin; α1-, α-2, β1-, β2- and γ-globulins; and the maximum degree of aggregation and the initial velocity of aggregation (slope) were evaluated. According to one-way analysis of variance, CRP and α1-, α-2, β1- and β2-globulins increased after exercise compared with rest condition (p < 0.001), whereas albumin and platelet aggregation showed lower values after exercise than at rest (p < 0.001). CRP and α1-globulin values were negatively correlated with both platelet aggregation indices at TPE5, whereas no significant correlation among these parameters was found at TREST, TPE30 and TPE60. This study provides evidence that an acute-phase response occurred in horses after the jumping exercise and suggests a linkage between the inflammatory status and the platelet responsiveness in horses during exercise.
ISSN:2076-3417
2076-3417
DOI:10.3390/app14052086