Task Force 1: The ACCF and AHA codes of conduct in human subjects research

• Published in: Journal of the American College of Cardiology Vol. 44; no. 8; pp. 1724 - 1728
• Main Authors: Alpert, Joseph S., Shine, Kenneth I., Adams, Robert J., Antman, Elliott M., Kavey, Rae Ellen W., Friedman, Lawrence, Frye, Robert L., Harrington, Robert A., Korn, David, Merz, Jon F., Ofili, Elizabeth
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 19.10.2004; Elsevier Limited
• Subjects: Advisory Committees; Cardiology; Cardiovascular Diseases - therapy; Clinical trials; Clinical Trials as Topic - legislation & jurisprudence; Codes; Conflict of Interest - legislation & jurisprudence; Ethics, Medical; Human Experimentation - legislation & jurisprudence; Human subjects; Humans; Informed consent; Informed Consent - legislation & jurisprudence; Mental Competency - legislation & jurisprudence; Participation; Pediatrics; Pharmaceutical industry; Research Design; Societies, Medical; Studies; Task forces; United States; United States; American Heart Association; Biomedical and Behavioral Research
• ISSN: 0735-1097; 1558-3597
• DOI: 10.1016/j.jacc.2004.08.038

Patients who participate in clinical trials, whether they receive experimental treatment or if they are in a control group, can benefit from meticulous attention to their care, by learning more about their disease process, and potentially, from the trial environment itself (6). Because results of research usually apply more directly to those patient groups included in the studies, it is especially important to include subjects from all socio-economic strata and all ethnic groups. In this setting, the potential for influence by factors unrelated to the best interest of the child, such as payment for participation, can significantly impact parental decision-making. [...]pediatric researchers are particularly obligated to strive for informed consent to the greatest extent possible.