The influence of urea on the penetration kinetics of topically applied corticosteroids
The effect of urea on the penetration of hydrocortisone and triamcinolone acetonide into human skin from topically applied vehicles was studied. The resulting penetration promotion has two possible applications in topical therapy: (a) An increased therapeutic effect for a given concentration of the...
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| Published in | Acta dermato-venereologica Vol. 64; no. 3; pp. 233 - 238 |
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| Main Author | |
| Format | Journal Article |
| Language | English |
| Published |
Uppsala
Acta dermato-venereologica
01.01.1984
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| Subjects | |
| Online Access | Get full text |
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| Abstract | The effect of urea on the penetration of hydrocortisone and triamcinolone acetonide into human skin from topically applied vehicles was studied. The resulting penetration promotion has two possible applications in topical therapy: (a) An increased therapeutic effect for a given concentration of the active constituent. (b) A given therapeutic effect could be obtained with a reduced concentration of the active ingredient. |
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| AbstractList | The effect of urea on the penetration of hydrocortisone and triamcinolone acetonide into human skin from topically applied vehicles was studied. The resulting penetration promotion has two possible applications in topical therapy: (a) An increased therapeutic effect for a given concentration of the active constituent. (b) A given therapeutic effect could be obtained with a reduced concentration of the active ingredient. |
| Author | WOHLRAB, W |
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| Keywords | Human Corticosteroid Urea Drug vehicle interaction Penetration Vehicle(excipient) Cortisol Skin Pharmacokinetics Topical administration Percutaneous route |
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| SubjectTerms | Administration, Topical Anti-Inflammatory Agents - administration & dosage Biological and medical sciences Drug Combinations Humans Hydrocortisone Kinetics Medical sciences Pharmacology. Drug treatments Skin Absorption - drug effects Skin, nail, hair, dermoskeleton Triamcinolone Acetonide - administration & dosage Urea - administration & dosage Urea - metabolism Urea - pharmacology |
| Title | The influence of urea on the penetration kinetics of topically applied corticosteroids |
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