The influence of urea on the penetration kinetics of topically applied corticosteroids

The effect of urea on the penetration of hydrocortisone and triamcinolone acetonide into human skin from topically applied vehicles was studied. The resulting penetration promotion has two possible applications in topical therapy: (a) An increased therapeutic effect for a given concentration of the...

Full description

Saved in:
Bibliographic Details
Published inActa dermato-venereologica Vol. 64; no. 3; pp. 233 - 238
Main Author WOHLRAB, W
Format Journal Article
LanguageEnglish
Published Uppsala Acta dermato-venereologica 01.01.1984
Subjects
Administration, Topical
Anti-Inflammatory Agents - administration & dosage
Biological and medical sciences
Drug Combinations
Humans
Hydrocortisone
Kinetics
Medical sciences
Pharmacology. Drug treatments
Skin Absorption - drug effects
Skin, nail, hair, dermoskeleton
Triamcinolone Acetonide - administration & dosage
Urea - administration & dosage
Urea - metabolism
Urea - pharmacology
Human
Corticosteroid
Urea
Drug vehicle interaction
Penetration
Vehicle(excipient)
Cortisol
Skin
Pharmacokinetics
Topical administration
Percutaneous route
Online AccessGet full text

Cover

More Information
Summary:The effect of urea on the penetration of hydrocortisone and triamcinolone acetonide into human skin from topically applied vehicles was studied. The resulting penetration promotion has two possible applications in topical therapy: (a) An increased therapeutic effect for a given concentration of the active constituent. (b) A given therapeutic effect could be obtained with a reduced concentration of the active ingredient.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0001-5555
1651-2057
DOI:10.2340/0001555564233238