Effects of rice bran fibre and cholestyramine on the faecal excretion of Kanechlor 600 (PCB) in rats

• Published in: Xenobiotica Vol. 21; no. 3; p. 351
• Main Authors: Takenaka, S, Morita, K, Tokiwa, H, Takahashi, K
• Format: Journal Article
• Language: English
• Published: England 1991
• Subjects: Animals; Body Weight - drug effects; Cholestyramine Resin - pharmacology; Diet; Eating - drug effects; Feces - chemistry; Male; Oryza; Polychlorinated Biphenyls - pharmacokinetics; Rats; Rats, Inbred Strains; Tissue Distribution
• ISSN: 0049-8254
• DOI: 10.3109/00498259109039475

1. As rice bran fibre binds Kanechlor 600 (PCB), the present study was conducted to determine whether the fibre stimulates rat faecal excretion of PCB in vivo. 2. In rats fed diets containing rice bran fibre, lignin and cholestyramine, the faecal excretion of PCB was increased. Total PCB excreted in rat faeces for groups fed diets of 10% (w/w) rice bran fibre, 10% fibre plus 5% lignin, 5% cholestyramine and 10% fibre plus 5% cholestyramine were 3.4, 3.7, 2.2 and 5.4 times as much, respectively, as that of control rats. The greatest effect on the faecal excretion of PCB was thus obtained with rice bran fibre plus cholestyramine. 3. In rats fed these diets, PCB concentration of the small intestine was significantly decreased to 25-50% of that of controls. PCB of spleen in rats fed diets of 10% fibre, 10% fibre plus 5% lignin and 10% fibre plus 5% cholestyramine also decreased to 50% of that of controls. However, PCB of other tissues were not affected.