A comprehensive nomenclature for serine proteases with homology to tissue kallikreins

• Published in: Biological chemistry Vol. 387; no. 6; pp. 637 - 641
• Main Authors: Lundwall, Åke, Band, Vimla, Blaber, Michael, Clements, Judith A., Courty, Yves, Diamandis, Eleftherios P., Fritz, Hans, Lilja, Hans, Malm, Johan, Maltais, Lois J., Yvonne Olsson, A., Petraki, Constantina, Scorilas, Andreas, Sotiropoulou, Georgia, Stenman, Ulf-Håkan, Stephan, Carsten, Talieri, Maroulio, Yousef, George M.
• Format: Journal Article
• Language: English
• Published: Germany Walter de Gruyter 01.06.2006
• Subjects: Basic Medicine; cancer; Chromosomes, Human, Pair 19; evolution; hormone; Humans; inflammation; kininogen; Läkemedelskemi; Medical and Health Sciences; Medicin och hälsovetenskap; Medicinal Chemistry; Medicinska och farmaceutiska grundvetenskaper; Sequence Homology; Serine Endopeptidases - genetics; Terminology as Topic; Tissue Kallikreins - genetics
• ISSN: 1431-6730; 1437-4315; 1437-4315
• DOI: 10.1515/BC.2006.082

The human kallikrein locus on chromosome 19q13.3–13.4 contains kallikrein 1 – the tissue kallikrein – and 14 related serine proteases. Recent investigations into their function and evolution have indicated that the present nomenclature for these proteins is inadequate or insufficient. Here we present a new nomenclature in which proteins without proven kininogenase activity are denoted kallikrein-related peptidase. Names are also given to the unique rodent proteins that are closely related to kallikrein 1.