Tityus bahiensis scorpion venom injected to dams during pregnancy affects some cytokines of fetuses

Due to the high incidence of scorpion stings in Brazil, pregnant women are among the possible victims. Cytokines are important during the pregnancy, and scorpion venoms can change their release. We evaluated the levels of some cytokines in the fetuses after the treatment of pregnant rats with the Ti...

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Published inToxicon (Oxford) Vol. 103; pp. 114 - 118
Main Authors Dorce, Ana L.C., Frare, Eduardo O., Paulo, Maria E.F.V., Dorce, Valquiria A.C., Nencioni, Ana L.A.
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.09.2015
Subjects
Animals
Brazil
Brazil - epidemiology
Cobalt
Cytokines
Cytokines - blood
Dams
Female
Fetus - drug effects
Fetus - metabolism
Fetuses
Incidence
Male
Pregnancy
Rats
Rats, Wistar
Reflexes
Scorpion Stings - epidemiology
Scorpion venom
Scorpion Venoms - toxicity
Scorpions - metabolism
Tityus bahiensis
Brazil
Pregnancy
Cytokines
Tityus bahiensis
Fetuses
Scorpion venom
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Summary:Due to the high incidence of scorpion stings in Brazil, pregnant women are among the possible victims. Cytokines are important during the pregnancy, and scorpion venoms can change their release. We evaluated the levels of some cytokines in the fetuses after the treatment of pregnant rats with the Tityus bahiensis scorpion venom. The concentration of some of them is altered and can be responsible for the effects previously observed on innate reflexes, and the physical and behavioral development of the offspring. •Scorpion venom applied to pregnant rats alters the cytokine levels in fetuses.•The alterations occurs mainly in GD16 group.•The alterations were sometimes consistent with the LPS reference and other times, not.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0041-0101
1879-3150
DOI:10.1016/j.toxicon.2015.06.023