Administration of a maple syrup extract to mitigate their hepatic inflammation induced by a high-fat diet: a transcriptome analysis

• Published in: Bioscience, biotechnology, and biochemistry Vol. 79; no. 11; pp. 1893 - 1897
• Main Authors: Kamei, Asuka, Watanabe, Yuki, Shinozaki, Fumika, Yasuoka, Akihito, Kondo, Takashi, Ishijima, Tomoko, Toyoda, Tsudoi, Arai, Soichi, Abe, Keiko
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 01.01.2015; Oxford University Press
• Subjects: Acer - chemistry; Animals; Diet, High-Fat - adverse effects; Gene Expression - drug effects; immune response; inflammation; Inflammation - drug therapy; Inflammation - pathology; lipid metabolism; Lipid Metabolism - drug effects; Lipid Metabolism - genetics; liver; Liver - drug effects; Liver - pathology; maple syrup; Mice; Plant Extracts - administration & dosage; Plant Extracts - chemistry; Transcriptome - drug effects; Transcriptome - genetics; liver; inflammation; immune response; maple syrup; lipid metabolism
• ISSN: 0916-8451; 1347-6947
• DOI: 10.1080/09168451.2015.1042833

Effects of the administration of maple syrup extract (MSX) on hepatic gene expression were investigated in mice fed a high-fat diet. Gene annotation enrichment analysis based on gene ontology revealed some changes in the expression of genes related to lipid metabolism and the immune response in MSX-fed mice. Detailed analysis of these data indicated that MSX ingestion mitigates hepatic inflammation.