Breakthroughs in bacterial resistance mechanisms and the potential ways to combat them

Multidrug-resistant (MDR) bacteria have increased at an alarming rate over recent decades and cause serious problems. The emergence of resistant infections caused by these bacteria has led to mortality and morbidity; consequently there is an urgent need to find solution for combating bacterial resis...

Full description

Saved in:
Bibliographic Details
Published inMicrobial pathogenesis Vol. 95; pp. 32 - 42
Main Authors Khameneh, Bahman, Diab, Roudayna, Ghazvini, Kiarash, Fazly Bazzaz, Bibi Sedigheh
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.06.2016
Subjects
Anti-Bacterial Agents - pharmacology
Antibacterial agents
Antibiotic-resistance mechanisms
Bacteria - drug effects
Biofilm
Combination therapy
Drug Resistance, Bacterial
Efflux pump
Nanoparticles
Nanoparticles - metabolism
Natural substances
Nanoparticles
Antibiotic-resistance mechanisms
Biofilm
Natural substances
Combination therapy
Antibacterial agents
Efflux pump
Online AccessGet full text

Cover

More Information
Summary:Multidrug-resistant (MDR) bacteria have increased at an alarming rate over recent decades and cause serious problems. The emergence of resistant infections caused by these bacteria has led to mortality and morbidity; consequently there is an urgent need to find solution for combating bacterial resistance. In the present paper, first, some mechanisms of antibiotic resistance such as changing the antibacterial agent's uptake and biofilm formation are discussed. Following, for removing the antibacterial resistance, a wide range of approaches like developing new generations of antibiotics, combination therapy, natural antibacterial substances and applying nanoparticulate systems have been explained. Among them, antibiotic delivery via nanoparticles, has been attracted more attention recently, so discussed in present review, separately. •Antimicrobial resistance is due to antibiotic efflux, antibiotic inactivation, biofilm formation.•Developing new generations of antibiotics solely is not promising approach to resolve the antibacterial resistance problem.•Using natural antibacterial substances provides a solution to combat microbial resistance.•Applying nanoparticulate systems is a potential strategy to counteract bacterial resistance to antimicrobial agents.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:0882-4010
1096-1208
DOI:10.1016/j.micpath.2016.02.009