The organization of frontostriatal brain wiring in non-affective early psychosis compared with healthy subjects using a novel diffusion imaging fiber cluster analysis

• Published in: Molecular psychiatry Vol. 28; no. 6; pp. 2301 - 2311
• Main Authors: Levitt, J. J., Zhang, F., Vangel, M., Nestor, P. G., Rathi, Y., Cetin-Karayumak, S., Kubicki, M., Coleman, M. J., Lewandowski, K. E., Holt, D. J., Keshavan, M., Bouix, S., Öngür, D., Breier, A., Shenton, M. E., O’Donnell, L. J.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.06.2023; Nature Publishing Group
• Subjects: 59/57; 631/378; 631/477; Behavioral Sciences; Biological Psychology; Brain - pathology; Brain architecture; Cadmium; Cluster analysis; Convergence; Cortex (frontal); Diffusion; Frontal gyrus; Healthy Volunteers; Hemispheric laterality; Humans; Magnetic resonance imaging; Medicine; Medicine & Public Health; Mental disorders; Neural networks; Neuroimaging; Neurosciences; Pharmacotherapy; Psychiatry; Psychosis; Psychotic Disorders - diagnostic imaging; Psychotic Disorders - pathology; Schizophrenia; Substantia alba; White Matter - pathology; Young Adult

Background Alterations in brain connectivity may underlie neuropsychiatric conditions such as schizophrenia. We here assessed the degree of convergence of frontostriatal fiber projections in 56 young adult healthy controls (HCs) and 108 matched Early Psychosis-Non-Affective patients (EP-NAs) using o...