Fat taste signal transduction and its possible negative modulator components
The incidence of obesity and its associated diseases including diabetes and various cardiovascular disease continues to escalate. Since the energy homeostasis executes a substantial role in fat-rich food intake and body weight regulation, it grows into a prevalent subject of interest for its strong...
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| Published in | Progress in lipid research Vol. 79; p. 101035 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Elsevier Ltd
01.07.2020
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| Subjects | |
| Online Access | Get full text |
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| Abstract | The incidence of obesity and its associated diseases including diabetes and various cardiovascular disease continues to escalate. Since the energy homeostasis executes a substantial role in fat-rich food intake and body weight regulation, it grows into a prevalent subject of interest for its strong energy density and high palatability. Over the decade, the notion that the dietary fatty acids convey signaling cues to oro-gustatory system embrace profound ability in understanding its function along with its perception of dietary fats. In this review, recent developments in the field of oleogustus and its downstream signaling mechanism in taste bud cells are analyzed. Notably, we made a brief attempt to expose the possible negative modulator components that had the potential to modulate the distinctive fat signal transduction components and its oro-gustatory mechanism. This review is in-sighted to urge the scientific community to work towards that goal to establish the libraries comprising both chemical and natural fat taste modifiers that adhere to fat taste receptors and alters its gustatory sense to proficiently combat obesity-linked complications.
•Is fat a taste? the data are strong but are they definite?•Recent evidence supports that a taste system for the oro-gustatory perception of fat exists in human and rodents•Cell signaling cascades altered by fatty acids play an important role in health and disease•Binding process of tastants with fat taste receptors and its signaling cascade could be the target for negative modulators |
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| AbstractList | The incidence of obesity and its associated diseases including diabetes and various cardiovascular disease continues to escalate. Since the energy homeostasis executes a substantial role in fat-rich food intake and body weight regulation, it grows into a prevalent subject of interest for its strong energy density and high palatability. Over the decade, the notion that the dietary fatty acids convey signaling cues to oro-gustatory system embrace profound ability in understanding its function along with its perception of dietary fats. In this review, recent developments in the field of oleogustus and its downstream signaling mechanism in taste bud cells are analyzed. Notably, we made a brief attempt to expose the possible negative modulator components that had the potential to modulate the distinctive fat signal transduction components and its oro-gustatory mechanism. This review is in-sighted to urge the scientific community to work towards that goal to establish the libraries comprising both chemical and natural fat taste modifiers that adhere to fat taste receptors and alters its gustatory sense to proficiently combat obesity-linked complications.The incidence of obesity and its associated diseases including diabetes and various cardiovascular disease continues to escalate. Since the energy homeostasis executes a substantial role in fat-rich food intake and body weight regulation, it grows into a prevalent subject of interest for its strong energy density and high palatability. Over the decade, the notion that the dietary fatty acids convey signaling cues to oro-gustatory system embrace profound ability in understanding its function along with its perception of dietary fats. In this review, recent developments in the field of oleogustus and its downstream signaling mechanism in taste bud cells are analyzed. Notably, we made a brief attempt to expose the possible negative modulator components that had the potential to modulate the distinctive fat signal transduction components and its oro-gustatory mechanism. This review is in-sighted to urge the scientific community to work towards that goal to establish the libraries comprising both chemical and natural fat taste modifiers that adhere to fat taste receptors and alters its gustatory sense to proficiently combat obesity-linked complications. The incidence of obesity and its associated diseases including diabetes and various cardiovascular disease continues to escalate. Since the energy homeostasis executes a substantial role in fat-rich food intake and body weight regulation, it grows into a prevalent subject of interest for its strong energy density and high palatability. Over the decade, the notion that the dietary fatty acids convey signaling cues to oro-gustatory system embrace profound ability in understanding its function along with its perception of dietary fats. In this review, recent developments in the field of oleogustus and its downstream signaling mechanism in taste bud cells are analyzed. Notably, we made a brief attempt to expose the possible negative modulator components that had the potential to modulate the distinctive fat signal transduction components and its oro-gustatory mechanism. This review is in-sighted to urge the scientific community to work towards that goal to establish the libraries comprising both chemical and natural fat taste modifiers that adhere to fat taste receptors and alters its gustatory sense to proficiently combat obesity-linked complications. The incidence of obesity and its associated diseases including diabetes and various cardiovascular disease continues to escalate. Since the energy homeostasis executes a substantial role in fat-rich food intake and body weight regulation, it grows into a prevalent subject of interest for its strong energy density and high palatability. Over the decade, the notion that the dietary fatty acids convey signaling cues to oro-gustatory system embrace profound ability in understanding its function along with its perception of dietary fats. In this review, recent developments in the field of oleogustus and its downstream signaling mechanism in taste bud cells are analyzed. Notably, we made a brief attempt to expose the possible negative modulator components that had the potential to modulate the distinctive fat signal transduction components and its oro-gustatory mechanism. This review is in-sighted to urge the scientific community to work towards that goal to establish the libraries comprising both chemical and natural fat taste modifiers that adhere to fat taste receptors and alters its gustatory sense to proficiently combat obesity-linked complications. •Is fat a taste? the data are strong but are they definite?•Recent evidence supports that a taste system for the oro-gustatory perception of fat exists in human and rodents•Cell signaling cascades altered by fatty acids play an important role in health and disease•Binding process of tastants with fat taste receptors and its signaling cascade could be the target for negative modulators |
| ArticleNumber | 101035 |
| Author | Muthuswamy, Karthi Krishnan, Vasanth Shanmugamprema, Deepankumar Subramaniam, Selvakumar Ponnusamy, Vinithra Subramanian, Gowtham |
| Author_xml | – sequence: 1 givenname: Deepankumar surname: Shanmugamprema fullname: Shanmugamprema, Deepankumar organization: Department of Biochemistry, Bharathiar University, Marudhamalai Road, Coimbatore, Tamil Nadu 641046, India – sequence: 2 givenname: Karthi surname: Muthuswamy fullname: Muthuswamy, Karthi organization: Department of Biochemistry, Bharathiar University, Marudhamalai Road, Coimbatore, Tamil Nadu 641046, India – sequence: 3 givenname: Gowtham surname: Subramanian fullname: Subramanian, Gowtham organization: Department of Biochemistry, Bharathiar University, Marudhamalai Road, Coimbatore, Tamil Nadu 641046, India – sequence: 4 givenname: Vinithra surname: Ponnusamy fullname: Ponnusamy, Vinithra organization: Department of Biochemistry, Bharathiar University, Marudhamalai Road, Coimbatore, Tamil Nadu 641046, India – sequence: 5 givenname: Vasanth surname: Krishnan fullname: Krishnan, Vasanth organization: Department of Botany, Bharathiar University, Marudhamalai Road, Coimbatore, Tamil Nadu 641046, India – sequence: 6 givenname: Selvakumar surname: Subramaniam fullname: Subramaniam, Selvakumar email: selvs20@yahoo.com organization: Department of Biochemistry, Bharathiar University, Marudhamalai Road, Coimbatore, Tamil Nadu 641046, India |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32437786$$D View this record in MEDLINE/PubMed |
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| Keywords | PLC Negative modulators Taste receptors LCFA AS-IV CALHM1 ERK1 TBC MA mTOR CD36 TRPM5 TPPO GLP-1 SOC TRCs MAPK IP3 SSO 4-AP TEA GPR120 STIM1 SAB LA Fat taste EPA GPCR DRK DHA 5-HT SFKs PIP2 CB1R |
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| Title | Fat taste signal transduction and its possible negative modulator components |
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