Fat taste signal transduction and its possible negative modulator components

• Published in: Progress in lipid research Vol. 79; p. 101035
• Main Authors: Shanmugamprema, Deepankumar, Muthuswamy, Karthi, Subramanian, Gowtham, Ponnusamy, Vinithra, Krishnan, Vasanth, Subramaniam, Selvakumar
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.07.2020
• Subjects: Animals; CD36; Fat taste; Fats - metabolism; GPR120; Humans; Negative modulators; Signal Transduction; Taste - physiology; Taste Perception - physiology; Taste receptors; PLC; Negative modulators; Taste receptors; LCFA; AS-IV; CALHM1; ERK1; TBC; MA; mTOR; CD36; TRPM5; TPPO; GLP-1; SOC; TRCs; MAPK; IP3; SSO; 4-AP; TEA; GPR120; STIM1; SAB; LA; Fat taste; EPA; GPCR; DRK; DHA; 5-HT; SFKs; PIP2; CB1R
• ISSN: 0163-7827; 1873-2194; 1873-2194
• DOI: 10.1016/j.plipres.2020.101035

The incidence of obesity and its associated diseases including diabetes and various cardiovascular disease continues to escalate. Since the energy homeostasis executes a substantial role in fat-rich food intake and body weight regulation, it grows into a prevalent subject of interest for its strong energy density and high palatability. Over the decade, the notion that the dietary fatty acids convey signaling cues to oro-gustatory system embrace profound ability in understanding its function along with its perception of dietary fats. In this review, recent developments in the field of oleogustus and its downstream signaling mechanism in taste bud cells are analyzed. Notably, we made a brief attempt to expose the possible negative modulator components that had the potential to modulate the distinctive fat signal transduction components and its oro-gustatory mechanism. This review is in-sighted to urge the scientific community to work towards that goal to establish the libraries comprising both chemical and natural fat taste modifiers that adhere to fat taste receptors and alters its gustatory sense to proficiently combat obesity-linked complications. •Is fat a taste? the data are strong but are they definite?•Recent evidence supports that a taste system for the oro-gustatory perception of fat exists in human and rodents•Cell signaling cascades altered by fatty acids play an important role in health and disease•Binding process of tastants with fat taste receptors and its signaling cascade could be the target for negative modulators