Synthesis, characterization and the antimicrobial activity of new eco-friendly ionic liquids

• Published in: Chemosphere (Oxford) Vol. 91; no. 11; pp. 1627 - 1634
• Main Authors: Messali, Mouslim, Moussa, Ziad, Alzahrani, Abdullah Y., El-Naggar, Moustafa Y., ElDouhaibi, Ahmad S., Judeh, Zaher M.A., Hammouti, Belkheir
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 01.06.2013; Elsevier
• Subjects: Anti-Infective Agents - chemical synthesis; Anti-Infective Agents - chemistry; Anti-Infective Agents - pharmacology; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antimicrobial activity; antimicrobial properties; Bacteria - drug effects; Biological and medical sciences; Candida albicans - drug effects; Chemistry; Chromatography, Liquid; Exact sciences and technology; General aspects; Green Chemistry Technology; Green procedure; Heterocyclic compounds; Heterocyclic compounds with several n hetero atoms in the same ring, in separated rings or in fused rings; ionic liquids; Ionic Liquids - chemical synthesis; Ionic Liquids - chemistry; Ionic Liquids - pharmacology; Magnetic Resonance Spectroscopy; Mass Spectrometry; Medical sciences; Microbial Sensitivity Tests; Microwave irradiation; microwave treatment; nuclear magnetic resonance spectroscopy; Organic chemistry; Pharmacology. Drug treatments; Preparations and properties; Spectrophotometry, Infrared; Symmetrical and unsymmetrical ionic liquids; Microwave irradiation; Antimicrobial activity; Symmetrical and unsymmetrical ionic liquids; Green procedure; Pseudomonadales; Candida albicans; Klebsiella; Bacillus subtilis; Bacillaceae; Antimicrobial agent; Ionic liquid; Fungi; Characterization; Pyridinium compounds; Bacillales; Bacteria; Pseudomonadaceae; Pseudomonas aeruginosa; Fungi Imperfecti; Chemical synthesis; Enterobacteriaceae; Microwave heating; Wasteless technology; Biological activity; Operating conditions; Organic dication
• ISSN: 0045-6535; 1879-1298
• DOI: 10.1016/j.chemosphere.2012.12.062

► A green synthesis of new eco friendly 1-alkyl-3-ethylimidazolium ionic liquids. ► The synthesis of a variety of new geminal dicationic ionic liquids is reported. ► The antimicrobial activity of some selected ILs is very interesting and promising. A green microwave-assisted procedure for the preparation of a series of 24 new 1-alkyl-3-ethylimidazolium ionic liquids with different functional groups in the alkyl chain is described. Moreover, the synthesis of a variety of ten new geminal dicationic ionic liquids is reported. Their structures were characterized by FT-IR, 1H NMR, 13C NMR, 11B, 19F, 31P, and mass spectrometry. Several ionic liquids were selected for antimicrobial activity studies, yielding very interesting and promising results.