COMPARISON OF THE EFFECTIVENESS OF FIVE DIFFERENT ANTIBIOTIC REGIMENS ON INFECTION WITH RICKETTSIA TYPHI: THERAPEUTIC DATA FROM 87 CASES

This study estimated the clinical effectiveness of five different antibiotic regimens (doxycycline, chloramphenicol, ciprofloxacin, doxycycline plus chloramphenicol, and doxycycline plus ciprofloxacin) administered for infection with Rickettsia typhi in terms of the duration of the fever. Eighty-sev...

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Published inThe American journal of tropical medicine and hygiene Vol. 70; no. 5; pp. 576 - 579
Main Authors GIKAS, ACHILLEAS, DOUKAKIS, STEPHANOS, PEDIADITIS, JOHN, KASTANAKIS, SERAFIM, MANIOS, ANDREAS, TSELENTIS, YIANNIS
Format Journal Article
LanguageEnglish
Published Lawrence, KS ASTMH 01.05.2004
Allen Press
Subjects
Adolescent
Adult
Aged
Aged, 80 and over
Anti-Bacterial Agents - therapeutic use
Biological and medical sciences
Drug Therapy, Combination - therapeutic use
Female
Humans
Infectious diseases
Male
Medical sciences
Middle Aged
Rickettsia typhi
Time Factors
Typhus, Endemic Flea-Borne - drug therapy
Human
Rickettsialosis
Infection
Rickettsiales
Antibiotic
Chemotherapy
Treatment
Efficiency
Rickettsial infection
Bacteriosis
Bacteria
Tropical medicine
Rickettsieae
Rickettsia typhi
Rickettsiaceae
Comparative study
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Summary:This study estimated the clinical effectiveness of five different antibiotic regimens (doxycycline, chloramphenicol, ciprofloxacin, doxycycline plus chloramphenicol, and doxycycline plus ciprofloxacin) administered for infection with Rickettsia typhi in terms of the duration of the fever. Eighty-seven patients with endemic typhus were hospitalized between 1993 and 1998 at the General Hospital of Chania in Chania, Crete, Greece. The mean time to defervescence was 2.9 days for doxycycline, 4.0 days for chloramphenicol, and 4.2 days for ciprofloxacin. In patients receiving combinations of doxycycline plus chloramphenicol and doxycycline plus ciprofloxacin, fever subsided in 3.4 and 4.0 days, respectively. The outcome was favorable in all patients, and no deaths or relapses were observed within two months.
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ISSN:0002-9637
1476-1645
DOI:10.4269/ajtmh.2004.70.576