A global perspective on FOXO1 in lipid metabolism and lipid-related diseases

• Published in: Progress in lipid research Vol. 66; pp. 42 - 49
• Main Authors: Li, Yue, Ma, Zhiqiang, Jiang, Shuai, Hu, Wei, Li, Tian, Di, Shouyin, Wang, Dongjin, Yang, Yang
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.04.2017
• Subjects: Adipocytes - cytology; Adipocytes - pathology; Animals; Disease; Forkhead box protein O1; Forkhead Box Protein O1 - metabolism; Gene Expression Regulation; Humans; Lipid Metabolism; Lipid-related diseases; Lipolysis; Lipid-related diseases; Forkhead box protein O1; Lipid metabolism
• ISSN: 0163-7827; 1873-2194; 1873-2194
• DOI: 10.1016/j.plipres.2017.04.002

Lipid metabolism is a complex physiological process that is involved in nutrient adjustment, hormone regulation, and homeostasis. An unhealthy lifestyle and chronic nutrient overload can cause lipid metabolism disorders, which may lead to serious lipid-related diseases, including obesity, non-alcoholic fatty liver disease (NAFLD), and type 2 diabetes mellitus (T2DM). Therefore, tools for preventing dysfunctional lipid metabolism are urgently needed. The transcription factor forkhead box protein O1 (FOXO1) is involved in lipid metabolism and plays a critical role in the development of lipid-related diseases. In this review, we provide a global perspective on the role of FOXO1 in lipid metabolism and lipid-related diseases. The information included here may be useful for the design of future studies and advancing investigations of FOXO1 as a therapeutic target.