Grafting antibiofilm polymer hydrogel film onto catheter by SARA SI-ATRP

• Published in: Journal of biomaterials science. Polymer ed. Vol. 29; no. 17; pp. 2106 - 2123
• Main Authors: Zhou, Chao, Song, Hongqin, Loh, Jia Ling Celestine, She, Jueqin, Deng, Linhong, Liu, Bo
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 01.12.2018; Taylor & Francis Ltd
• Subjects: Allyl Compounds - chemistry; Anti-Bacterial Agents - chemistry; antibacterial property; antibiofilm coating; Biofilms; Catheters; cationic polymer; Coated Materials, Biocompatible - chemistry; Cross-Linking Reagents - chemistry; Dimethylpolysiloxanes - chemistry; Hydrogels - chemistry; log reduction; Methacrylates - chemistry; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Polyethylene Glycols - chemistry; Polylysine - chemistry; Polymerization; Polymethacrylic Acids - chemistry; Quaternary Ammonium Compounds - chemistry; SARA SI-ATRP; Staphylococcus infections; Surface modification; Surface Properties; Vancomycin-Resistant Enterococci; SARA SI-ATRP; log reduction; Surface modification; cationic polymer; antibacterial property; antibiofilm coating
• ISSN: 0920-5063; 1568-5624
• DOI: 10.1080/09205063.2018.1507268

Catheters are widely used and play an important role in medicine. However, catheter-associated infection is prevalent even under stringent sterile conditions. Biofilms are formed when bacteria populate the surfaces of catheters. This makes the biofilm resistant to antibiotics. Hence, it is imperative for there to be an inherently antifouling and anti-bacterial catheter to mitigate the formation of biofilm. This paper aims to outline the synthesis of non-leachable anti-biofilm and anti-bacterial cationic film coatings through direct polymerization using supplemental activator and reducing agent surface initiated atom transfer radical polymerization (SARA SI-ATRP). Three crosslinked cationic coatings comprising of Diallyl dimethyl ammonium chloride (DADMAC), or ε-poly-L-lysine HCl methacrylic acid (EPL-MA) together with a crosslinker (polyethylene glycol dimethacrylate, PEGDMA) were investigated. These non-leachable covalently linked coatings with DADMAC can achieve more than 2 log reduction (99.0%) with Methicillin-resistant Staphylococcus aureus (MRSA) and 1.25 log reduction (94.4%) with Vancomycin resistant Enterococcus (VRE) in in vitro studies.