A Guide to Topical Vehicle Formulations

• Published in: Journal of cutaneous medicine and surgery Vol. 22; no. 2; p. 207
• Main Authors: Mayba, Julia N, Gooderham, Melinda J
• Format: Journal Article
• Language: English
• Published: United States 01.03.2018
• Subjects: Administration, Topical; Dermatologic Agents - administration & dosage; Dermatologic Agents - chemistry; Dermatologic Agents - therapeutic use; Drug Delivery Systems; Humans; Medication Adherence; Pharmaceutical Vehicles; Skin Cream; drug delivery systems; medication adherence; topical administration; topical formulations
• ISSN: 1615-7109
• DOI: 10.1177/1203475417743234

Adherence to topical treatment for a variety of chronic skin conditions, such as psoriasis, acne, and atopic dermatitis, is known to be very poor. A number of factors contribute to this phenomenon, including lack of treatment efficacy and patient concerns regarding side effects, among others. At the forefront of barriers facing optimal patient adherence to topical treatment is choosing the ideal topical vehicle formulation. Medical professionals have demonstrated a lack of understanding with respect to the composition and nomenclature of the various topical formulations. In this review, we clarify the properties and definitions of the following topical formulations: ointments, creams, lotions, topical solutions, topical suspensions, gels, foams, and sprays. We also provide suggested areas of application for the aforementioned formulations and a succinct, patient-geared summary of their advantages and disadvantages. This review hopes to deliver a clear and concise practical summary of the most commonly encountered topical formulations for the treatment of cutaneous disease for medical professionals. This will allow clinicians to provide their patients with accurate information to facilitate informed choice of topical formulation, which may serve to improve treatment adherence.