Dalestones A and B, two anti-inflammatory cyclopentenones from Daldinia eschscholzii with an edited strong promoter for the global regulator LaeA-like gene

Replacement of the native promoter of theglobal regulator LaeA-like gene of Daldinia eschscholzii by a strong gpdA promoter led to the generation of two novel cyclopentenone metabolites, named dalestones A and B, whose structures were assigned by a combination of spectroscopic analysis, modified Mos...

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Published inChinese journal of natural medicines Vol. 17; no. 5; pp. 387 - 393
Main Authors ZHOU, Zhen-Zhen, ZHU, Hong-Jie, YANG, Cheng-Long, LIU, Yan-Jun, JIANG, Nan, XIAO, Yong-Sheng, SHI, Li-Yun, JIAO, Rui-Hua, GE, Hui-Ming, TAN, Ren-Xiang
Format Journal Article
LanguageEnglish
Published China Elsevier B.V 20.05.2019
Subjects
Animals
Anti-Inflammatory Agents - chemistry
Anti-Inflammatory Agents - isolation & purification
Anti-Inflammatory Agents - metabolism
Anti-Inflammatory Agents - pharmacology
circular dichroism spectroscopy
Cyclopentanes - chemistry
Cyclopentanes - isolation & purification
Cyclopentanes - metabolism
Cyclopentanes - pharmacology
Cyclopentenone
Daldinia
Daldinia eschscholzii
Fungal Proteins - genetics
Fungal Proteins - metabolism
genes
Global regulator
interleukin-6
Interleukin-6 - metabolism
Lipopolysaccharides - pharmacology
macrophages
Macrophages - drug effects
Macrophages - metabolism
metabolites
Mice
Molecular Structure
Oriental traditional medicine
Promoter Regions, Genetic - genetics
RAW 264.7 Cells
spectral analysis
Transcription Factors - genetics
Transcription Factors - metabolism
tumor necrosis factor-alpha
Tumor Necrosis Factor-alpha - metabolism
Xylariales - chemistry
Xylariales - genetics
Xylariales - metabolism
Cyclopentenone
Daldinia eschscholzii
Global regulator
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Summary:Replacement of the native promoter of theglobal regulator LaeA-like gene of Daldinia eschscholzii by a strong gpdA promoter led to the generation of two novel cyclopentenone metabolites, named dalestones A and B, whose structures were assigned by a combination of spectroscopic analysis, modified Mosher’s reaction, and electronic circular dichroism (ECD). Dalestones A and B inhibit the gene expression of TNF-α and IL-6 in LPS-induced RAW264.7 macrophages.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1875-5364
1875-5364
DOI:10.1016/S1875-5364(19)30045-7