Recent Advancement of Molecular Structure and Biomaterial Function of Chitosan from Marine Organisms for Pharmaceutical and Nutraceutical Application

Chitosan is an innate cationic biological polysaccharide polymer, naturally obtained from chitin deacetylation, that possesses broad-spectrum properties such as antibacterial, biodegradability, biocompatibility, non-toxic, non-immunogenicity, and so on. Chitosan can be easily modified owing to its m...

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Published inApplied sciences Vol. 10; no. 14; p. 4719
Main Authors Li, Bailei, Elango, Jeevithan, Wu, Wenhui
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 01.07.2020
Subjects
Biocompatibility
Biodegradability
Biodegradation
Biological activity
Biomaterials
Biomedical materials
Cancer
Cationic polymerization
Caustic soda
Chitin
Chitosan
Composition
Crustaceans
Deacetylation
Equipment and supplies
Functional foods
Functional foods & nutraceuticals
Hydroxyl groups
Immunogenicity
Marine fauna
Marine organisms
Materials
Mechanical properties
modification
Molecular chains
Molecular structure
pharmaceutical application
Pharmaceutical industry
Pharmaceuticals
Polymers
Polysaccharides
Product development
Properties
Structure
Structure-function relationships
Wound healing
China
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Summary:Chitosan is an innate cationic biological polysaccharide polymer, naturally obtained from chitin deacetylation, that possesses broad-spectrum properties such as antibacterial, biodegradability, biocompatibility, non-toxic, non-immunogenicity, and so on. Chitosan can be easily modified owing to its molecular chain that contains abundant active amino and hydroxyl groups, through various modifications. Not only does it possess excellent properties but it also greatly accelerates its solubility and endows it with additional special properties. It can be developed into bioactive materials with innovative properties, functions, and multiple uses, especially in the biomedical fields. In this paper, the unique properties and the relationship between the molecular structure of chitosan and its derivatives are emphasized, an overview of various excellent biomedical properties of chitosan and its current progress in the pharmaceutical and nutraceutical field have prospected, to provide the theoretical basis for better development and utilization of new biomedical materials of chitosan and its derivatives.
ISSN:2076-3417
2076-3417
DOI:10.3390/app10144719