Triterpenoid saponins and phenylpropanoid glycoside from the roots of Ardisia crenata and their cytotoxic activities

Two new triterpenoid saponins, ardisicrenoside R and S (1 and 2), and one new phenylpropanoid glycoside, ardicrephenin (3), along with five known compounds (4−8), were isolated from roots of Ardisia crenata. Their structures were elucidated on the basis of NMR spectroscopic data and chemical methods...

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Published inChinese journal of natural medicines Vol. 19; no. 1; pp. 63 - 69
Main Authors SONG, Ning-Ning, YANG, Lei-Min, ZHANG, Min-Jie, AN, Ren-Feng, LIU, Wei, HUANG, Xue-Feng
Format Journal Article
LanguageEnglish
Published China Elsevier B.V 01.01.2021
Subjects
Ardisia
Ardisia crenata
Cytotoxicity
Phenylpropanoid glycoside
spectral analysis
Triterpenoid saponins
Cytotoxicity
Ardisia crenata
Phenylpropanoid glycoside
Triterpenoid saponins
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Summary:Two new triterpenoid saponins, ardisicrenoside R and S (1 and 2), and one new phenylpropanoid glycoside, ardicrephenin (3), along with five known compounds (4−8), were isolated from roots of Ardisia crenata. Their structures were elucidated on the basis of NMR spectroscopic data and chemical methods. Compounds 2−7 were evaluated for their cytotoxic activities against A549, MCF-7, HepG2 and MDA-MB-231 cell lines by MTT assay. Ardicrenin (6) showed significant cytotoxicity, with IC50 values of 1.17 ± 0.01, 1.19 ± 0.06, 3.52 ± 0.23, and 16.61 ± 1.02 μmol·L−1, respectively.
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ISSN:1875-5364
1875-5364
DOI:10.1016/S1875-5364(21)60007-9