Anticancer and multidrug-resistance reversing potential of traditional medicinal plants and their bioactive compounds in leukemia cell lines

Multidrug resistance remains a serious clinical problem in the successful therapy of malignant diseases. It occurs in cultured tumor cell lines, as well as in human cancers. Therefore, it is critical to develop novel anticancer drugs with multidrug-resistance modulating potential to increase the sur...

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Published inChinese journal of natural medicines Vol. 12; no. 12; pp. 881 - 894
Main Authors Senthilkumar, Ravichandran, CHEN, Bao-An, CAI, Xiao-Hui, FU, Rong
Format Journal Article
LanguageEnglish
Published China Elsevier B.V 01.12.2014
Subjects
antineoplastic agents
Antineoplastic Agents, Phytogenic - pharmacology
Antineoplastic Agents, Phytogenic - therapeutic use
Apoptosis
bioactive compounds
Cell Line, Tumor
cell lines
Drug Resistance, Multiple - drug effects
Humans
Leukemia
Leukemia - drug therapy
Magnoliopsida - chemistry
medicinal plants
Multidrug resistance (MDR)
multiple drug resistance
neoplasm cells
Oriental traditional medicine
patients
Phytotherapy
Plant Extracts - pharmacology
Plant Extracts - therapeutic use
Plants, Medicinal - chemistry
Reversal multidrug resistance
survival rate
therapeutics
Traditional medicinal plants
Multidrug resistance (MDR)
Reversal multidrug resistance
Traditional medicinal plants
Leukemia
Apoptosis
Online AccessGet full text
ISSN1875-5364
1875-5364
DOI10.1016/S1875-5364(14)60131-X

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Abstract Multidrug resistance remains a serious clinical problem in the successful therapy of malignant diseases. It occurs in cultured tumor cell lines, as well as in human cancers. Therefore, it is critical to develop novel anticancer drugs with multidrug-resistance modulating potential to increase the survival rate of leukemia patients. Plant-derived natural products have been used for the treatment of various diseases for thousands of years. This review summarizes the anticancer and multidrug-resistance reversing properties of the extracts and bioactive compounds from traditional medicinal plants in different leukemia cell lines. Further mechanistic studies will pave the road to establish the anticancer potential of plant-derived natural compounds.
AbstractList Multidrug resistance remains a serious clinical problem in the successful therapy of malignant diseases. It occurs in cultured tumor cell lines, as well as in human cancers. Therefore, it is critical to develop novel anticancer drugs with multidrug-resistance modulating potential to increase the survival rate of leukemia patients. Plant-derived natural products have been used for the treatment of various diseases for thousands of years. This review summarizes the anticancer and multidrug-resistance reversing properties of the extracts and bioactive compounds from traditional medicinal plants in different leukemia cell lines. Further mechanistic studies will pave the road to establish the anticancer potential of plant-derived natural compounds.Multidrug resistance remains a serious clinical problem in the successful therapy of malignant diseases. It occurs in cultured tumor cell lines, as well as in human cancers. Therefore, it is critical to develop novel anticancer drugs with multidrug-resistance modulating potential to increase the survival rate of leukemia patients. Plant-derived natural products have been used for the treatment of various diseases for thousands of years. This review summarizes the anticancer and multidrug-resistance reversing properties of the extracts and bioactive compounds from traditional medicinal plants in different leukemia cell lines. Further mechanistic studies will pave the road to establish the anticancer potential of plant-derived natural compounds.
Multidrug resistance remains a serious clinical problem in the successful therapy of malignant diseases. It occurs in cultured tumor cell lines, as well as in human cancers. Therefore, it is critical to develop novel anticancer drugs with multidrug-resistance modulating potential to increase the survival rate of leukemia patients. Plant-derived natural products have been used for the treatment of various diseases for thousands of years. This review summarizes the anticancer and multidrug-resistance reversing properties of the extracts and bioactive compounds from traditional medicinal plants in different leukemia cell lines. Further mechanistic studies will pave the road to establish the anticancer potential of plant-derived natural compounds.
Multidrug resistance remains a serious clinical problem in the successful therapy of malignant diseases. It occurs in cultured tumor cell lines, as well as in human cancers. Therefore, it is critical to develop novel anticancer drugs with multidrug-resistance modulating potential to increase the survival rate of leukemia patients. Plant-derived natural products have been used for the treatment of various diseases for thousands of years. This review summarizes the anticancer and multidrug-resistance reversing properties of the extracts and bioactive compounds from traditional medicinal plants in different leukemia cell lines. Further mechanistic studies will pave the road to establish the anticancer potential of plant-derived natural compounds. Key Words * Traditional medicinal plants * Leukemia * Multidrug resistance (MDR) * Reversal multidrug resistance * Apoptosis
Author CAI, Xiao-Hui
FU, Rong
CHEN, Bao-An
Senthilkumar, Ravichandran
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  givenname: Bao-An
  surname: CHEN
  fullname: CHEN, Bao-An
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  givenname: Xiao-Hui
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  organization: State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Carcinogenesis and Intervention, China Pharmaceutical University, Nanjing 210009, China
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Issue 12
Keywords Multidrug resistance (MDR)
Reversal multidrug resistance
Traditional medicinal plants
Leukemia
Apoptosis
Language English
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Snippet Multidrug resistance remains a serious clinical problem in the successful therapy of malignant diseases. It occurs in cultured tumor cell lines, as well as in...
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SubjectTerms antineoplastic agents
Antineoplastic Agents, Phytogenic - pharmacology
Antineoplastic Agents, Phytogenic - therapeutic use
Apoptosis
bioactive compounds
Cell Line, Tumor
cell lines
Drug Resistance, Multiple - drug effects
Humans
Leukemia
Leukemia - drug therapy
Magnoliopsida - chemistry
medicinal plants
Multidrug resistance (MDR)
multiple drug resistance
neoplasm cells
Oriental traditional medicine
patients
Phytotherapy
Plant Extracts - pharmacology
Plant Extracts - therapeutic use
Plants, Medicinal - chemistry
Reversal multidrug resistance
survival rate
therapeutics
Traditional medicinal plants
Title Anticancer and multidrug-resistance reversing potential of traditional medicinal plants and their bioactive compounds in leukemia cell lines
URI https://dx.doi.org/10.1016/S1875-5364(14)60131-X
https://www.ncbi.nlm.nih.gov/pubmed/25556059
https://www.proquest.com/docview/1642606995
https://www.proquest.com/docview/1660403373
https://www.proquest.com/docview/2116931153
Volume 12
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