Anticancer and multidrug-resistance reversing potential of traditional medicinal plants and their bioactive compounds in leukemia cell lines

• Published in: Chinese journal of natural medicines Vol. 12; no. 12; pp. 881 - 894
• Main Authors: Senthilkumar, Ravichandran, CHEN, Bao-An, CAI, Xiao-Hui, FU, Rong
• Format: Journal Article
• Language: English
• Published: China Elsevier B.V 01.12.2014
• Subjects: antineoplastic agents; Antineoplastic Agents, Phytogenic - pharmacology; Antineoplastic Agents, Phytogenic - therapeutic use; Apoptosis; bioactive compounds; Cell Line, Tumor; cell lines; Drug Resistance, Multiple - drug effects; Humans; Leukemia; Leukemia - drug therapy; Magnoliopsida - chemistry; medicinal plants; Multidrug resistance (MDR); multiple drug resistance; neoplasm cells; Oriental traditional medicine; patients; Phytotherapy; Plant Extracts - pharmacology; Plant Extracts - therapeutic use; Plants, Medicinal - chemistry; Reversal multidrug resistance; survival rate; therapeutics; Traditional medicinal plants; Multidrug resistance (MDR); Reversal multidrug resistance; Traditional medicinal plants; Leukemia; Apoptosis
• ISSN: 1875-5364; 1875-5364
• DOI: 10.1016/S1875-5364(14)60131-X

Multidrug resistance remains a serious clinical problem in the successful therapy of malignant diseases. It occurs in cultured tumor cell lines, as well as in human cancers. Therefore, it is critical to develop novel anticancer drugs with multidrug-resistance modulating potential to increase the survival rate of leukemia patients. Plant-derived natural products have been used for the treatment of various diseases for thousands of years. This review summarizes the anticancer and multidrug-resistance reversing properties of the extracts and bioactive compounds from traditional medicinal plants in different leukemia cell lines. Further mechanistic studies will pave the road to establish the anticancer potential of plant-derived natural compounds.