Functional Imaging Before and After Constraint-Induced Language Therapy for Aphasia Using Magnetoencephalography

Five patients with chronic aphasia underwent functional imaging using magnetoencephalography (MEG) before and after constraint-induced language therapy (CILT). Patients who responded well to CILT exhibited a greater degree of late MEG activation in posterior language areas of the left hemisphere and...

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Bibliographic Details
Published inNeurocase Vol. 12; no. 6; pp. 322 - 331
Main Authors Breier, Joshua I., Maher, Lynn M., Novak, Barbra, Papanicolaou, Andrew C.
Format Journal Article
LanguageEnglish
Published England Taylor & Francis Group 01.12.2006
Subjects
Aged
Aphasia - diagnosis
Aphasia - physiopathology
Aphasia - therapy
Brain Mapping - methods
Causality
Cerebral Cortex - anatomy & histology
Cerebral Cortex - physiopathology
Educational Status
Female
Functional Laterality - physiology
Humans
Language
Language Tests
Language Therapy - methods
Language Therapy - trends
Magnetic Resonance Imaging
Magnetoencephalography - methods
Magnetoencephalography - trends
Male
Middle Aged
Predictive Value of Tests
Reaction Time - physiology
Recovery of Function - physiology
Treatment Outcome
Verbal Behavior - physiology
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Summary:Five patients with chronic aphasia underwent functional imaging using magnetoencephalography (MEG) before and after constraint-induced language therapy (CILT). Patients who responded well to CILT exhibited a greater degree of late MEG activation in posterior language areas of the left hemisphere and homotopic areas of the right hemisphere prior to therapy than those who did not respond well. Response to CILT, however, was positively correlated with the degree of pre-therapy MEG activity within posterior areas of the right hemisphere only on an individual basis.
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ISSN:1355-4794
1465-3656
DOI:10.1080/13554790601126054