Advantages of Dynamic Navigation in Prosthetic Implant Treatment in Terms of the Clinical Evaluation and Salivary Pro-Inflammatory Biomarkers: A Clinical Study

• Published in: Applied sciences Vol. 13; no. 17; p. 9866
• Main Authors: Wachol, Kacper, Morawiec, Tadeusz, Szurko, Agnieszka, Baldi, Domenico, Nowak-Wachol, Anna, Śmieszek-Wilczewska, Joanna, Mertas, Anna
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 01.08.2023
• Subjects: Antibodies; Biological markers; Biomarkers; Bones; C-reactive protein; Clinical trials; cytokine; Cytokines; Density; dentistry; Disease; Enzymes; flapless implantology; Health aspects; Immunoassay; Implant dentures; implantology; Infections; Inflammation; Interleukins; Medical research; Medicine, Experimental; Patients; Prostheses; Proteins; saliva; Sinuses; Surgery; Transplants & implants; Poland; United States > US
• ISSN: 2076-3417; 2076-3417
• DOI: 10.3390/app13179866

Successful implantation in augmented areas relies on adequate bone density and quality, along with thorough planning. The minimisation of the risks involved in the surgery and recovery phases is also of tremendous relevance. The aims of the present research were to clinically and biochemically evaluate the healing process after implant surgery (dental implants) using dynamic surgical navigation following prior bone augmentation. Thirty healthy patients who had implant treatment were analysed. The study participants (30 patients) were randomised between two groups. The 15 patients in the study group were treated with Navident dynamic navigation by using a flapless technique. The control group included 15 subjects in whom the implantation procedure was performed classically using the elevation flap full-thickness method. In all cases, the patient’s clinical condition, the patient’s subjective visual assessment of post-operative pain using the Visual Analogue Scale (VAS), and the levels of the salivary biomarkers interleukin 6 (IL 6) and C-reactive protein (CRP) immediately before surgery on the first post-operative day and on the seventh post-operative day were assessed. The healing process was shown to be faster in patients in the study group due to the low invasiveness of the treatment, which was confirmed by lower levels of pro-inflammatory cytokines in the study group versus the control group. The statistical analysis used Student’s t-test and Mann–Whitney test. The implementation of dynamic navigation and the application of the flapless technique reduced post-operative trauma, leading to a reduced risk of infection, reduced patient discomfort, and faster recovery.