Oxidants, oxidative stress and the biology of ageing

Living in an oxygenated environment has required the evolution of effective cellular strategies to detect and detoxify metabolites of molecular oxygen known as reactive oxygen species. Here we review evidence that the appropriate and inappropriate production of oxidants, together with the ability of...

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Bibliographic Details
Published inNature (London) Vol. 408; no. 6809; pp. 239 - 247
Main Authors Finkel, Toren, Holbrook, Nikki J
Format Journal Article
LanguageEnglish
Published England Nature Publishing Group 09.11.2000
Subjects
Active oxygen
Aging
Aging - physiology
Animals
Biology
Cells
Cellular Senescence - physiology
Energy Intake
Genetic aspects
Humans
Life span
Longevity
Metabolites
Oxidants - physiology
Oxidative Stress
Oxidizing agents
Oxygen
Physiological aspects
Reactive Oxygen Species
Signal Transduction
United States
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Summary:Living in an oxygenated environment has required the evolution of effective cellular strategies to detect and detoxify metabolites of molecular oxygen known as reactive oxygen species. Here we review evidence that the appropriate and inappropriate production of oxidants, together with the ability of organisms to respond to oxidative stress, is intricately connected to ageing and life span.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
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ISSN:0028-0836
1476-4687
DOI:10.1038/35041687