Gelatine-based drug-eluting bandage contact lenses: Effect of PEGDA concentration and manufacturing technique

• Published in: International journal of pharmaceutics Vol. 599; p. 120452
• Main Authors: Zidan, Ghada, Greene, Carol A., Etxabide, Alaitz, Rupenthal, Ilva D., Seyfoddin, Ali
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 15.04.2021
• Subjects: 3D printing; Corneal bandages; Dexamethasone; GelMA; Ocular drug delivery; Polyethylene glycol diacrylate; PBS; Polyethylene glycol diacrylate; Dexamethasone; DEX; BCLs; PEGDA; Corneal bandages; GelMA; LAP; Ocular drug delivery; 3D printing
• ISSN: 0378-5173; 1873-3476
• DOI: 10.1016/j.ijpharm.2021.120452

[Display omitted] Drug-eluting bandage contact lenses (BCLs) have been widely studied as an alternative to eye drops due to their ability to increase the drug residence time and bioavailability as well as improve patient compliance. While silicone hydrogel polymers are commonly used in drug-eluting BCLs due to their transparency, mechanical properties and high oxygen permeability, gelatine hydrogels are also clear, flexible and have high oxygen permeability and may therefore be suitable contact lens materials. Moreover, the rheological properties of gelatine hydrogels allow their use as inks in extrusion-based 3D printers, therefore opening the door to a wide range of applications. Drug-loaded gelatine methacryloyl (GelMA) BCLs with different concentrations of poly (ethylene glycol) diacrylate (PEGDA) were prepared using solvent casting and 3D printing. The prepared lenses were characterised for their swelling ratio, in vitro degradation, and drug release properties. The results showed that the incorporation of 10% PEGDA improved the lenses’ resistance to handling and protected them during degradation testing, reduced the swelling ratio and prolonged the release of dexamethasone (DEX). Both techniques were deemed suitable to use in the manufacturing of drug-eluting BCLs noting that the optimal formulation may vary according to the preparation technique utilised.