The miR-24-3p/p130Cas: a novel axis regulating the migration and invasion of cancer cells

MicroRNAs (miRNAs) are small non-coding RNAs that negatively regulate gene expression by suppressing translation or facilitating mRNA decay. Differential expression of miRNAs is involved in the pathogenesis of several diseases including cancer. Here, we investigated the role of-miR-24-3p as a downre...

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Published inScientific reports Vol. 7; no. 1; p. 44847
Main Authors Kang, Hoin, Rho, Jun Gi, Kim, Chongtae, Tak, Hyosun, Lee, Heejin, Ji, Eunbyul, Ahn, Sojin, Shin, A-Ri, Cho, Hyun-Il, Huh, Yun Hyun, Song, Woo Keun, Kim, Wook, Lee, Eun Kyung
Format Journal Article
LanguageEnglish
Published England Nature Publishing Group 24.03.2017
Subjects
Cancer
Cell adhesion & migration
Cell migration
Cell proliferation
Ectopic expression
Gene expression
Metastases
Metastasis
MicroRNAs
miRNA
mRNA turnover
Non-coding RNA
Tumor suppressor genes
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Summary:MicroRNAs (miRNAs) are small non-coding RNAs that negatively regulate gene expression by suppressing translation or facilitating mRNA decay. Differential expression of miRNAs is involved in the pathogenesis of several diseases including cancer. Here, we investigated the role of-miR-24-3p as a downregulated miRNA in metastatic cancer. miR-24-3p was decreased in metastatic cancer and lower expression of miR-24-3p was related to poor survival of cancer patients. Consistently, ectopic expression of miR-24-3p suppressed the cell migration, invasion, and proliferation of MCF7, Hep3B, B16F10, SK-Hep1, and PC-3 cells by directly targeting p130Cas. Stable expression of p130Cas restored miR-24-3p-mediated inhibition of cell migration and invasion. These results suggest that miR-24-3p functions as a tumor suppressor and the miR-24-3p/p130Cas axis is a novel factor of cancer progression by regulating cell migration and invasion.
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ISSN:2045-2322
2045-2322
DOI:10.1038/srep44847