Bromoanaindolone, a novel antimicrobial exometabolite from the cyanobacterium Anabaena constricta

A new brominated indole alkaloid, designated as bromoanaindolone, was isolated from culture media of the cyanobacterium Anabaena constricta and was identified as 6-bromo-3-hydroxy-3-methyl-indol-2-one with a slight excess of the (3R) enantiomer. The molecular structure was elucidated on the basis of...

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Bibliographic Details
Published inNatural product research Vol. 23; no. 7; pp. 607 - 612
Main Authors Volk, R.-B., Girreser, U., Al-Refai, M., Laatsch, H.
Format Journal Article
LanguageEnglish
Published England Taylor & Francis Group 01.01.2009
Subjects
Anabaena - chemistry
Anabaena constricta
Anti-Infective Agents - isolation & purification
antimicrobial activity
brominated indole alkaloid
Bromine Compounds - isolation & purification
Cyanobacteria
exometabolite
Indoles - isolation & purification
Magnetic Resonance Spectroscopy
Mass Spectrometry
Molecular Structure
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Summary:A new brominated indole alkaloid, designated as bromoanaindolone, was isolated from culture media of the cyanobacterium Anabaena constricta and was identified as 6-bromo-3-hydroxy-3-methyl-indol-2-one with a slight excess of the (3R) enantiomer. The molecular structure was elucidated on the basis of IR, MS and NMR data. This extracellular metabolite of A. constricta possessed antimicrobial (anticyanobacterial and antibacterial) activity in different test systems, such as suspension and porous matrix tests.
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ISSN:1478-6419
1478-6427
DOI:10.1080/14786410802114068