Genetic regulation of slowly progressing mild muscle atrophy in fast-twitch muscles of BUF/Mna rats

• Published in: Muscle & nerve Vol. 20; no. 10; pp. 1258 - 1263
• Main Authors: Amo, Hiroyuki, Saito, Mitsuhiro, Nagao, Shizuko, Yagiu, Shigeru, Takahashi, Hisahide, Morita, Hiroyuki, Morita, Takako Matsuyama, Matsuyama, Mutsushi
• Format: Journal Article
• Language: English
• Published: New York John Wiley & Sons, Inc 01.10.1997; Wiley
• Subjects: Animals; Biological and medical sciences; Disease Progression; Diseases of striated muscles. Neuromuscular diseases; dominant trait; Gene Expression Regulation; Genes, Dominant; Genetic Predisposition to Disease; Hybridization, Genetic; Mas-1; Mas-2; Medical sciences; mild muscle atrophy susceptible genes; Muscle Fibers, Fast-Twitch - physiology; Muscular Atrophy - genetics; Muscular Atrophy - physiopathology; Neurology; Rats; Rats, Inbred BUF - genetics; Rats, Inbred BUF - physiology; Rats, Inbred Strains - genetics; Space life sciences; Atrophy; Animal model; Vertebrata; Striated muscle disease; Mammalia; Gene; Rat; Animal; Rodentia; Fast striated muscle; Genetics; Myopathy
• ISSN: 0148-639X; 1097-4598
• DOI: 10.1002/(SICI)1097-4598(199710)20:10<1258::AID-MUS8>3.0.CO;2-B

BUF/Mna strain rats spontaneously develop slowly progressing mild‐moderate muscle atrophy of extensor digitorum longus, tibialis, and extraocular muscles, which consist mainly of fast‐twitch type fibers, at nearly 100% incidence. They have lighter extensor digitorum longus muscles than soleus muscles, when alive for more than 6 weeks. Genetic segregation of the development of the muscle atrophy was studied by crossing the BUF/Mna strain with three other strains, ACI/NMs, WKY/NCrj, and BDIX, which were free of muscle atrophy. Two autosomal dominant susceptible genes, Mas‐1 and Mas‐2, determine the development of the muscle atrophy in these combinations of crosses. © 1997 John Wiley & Sons, Inc. Muscle Nerve 20: 1258–1263, 1997