Vitamins C and E in the latency period in women with preterm premature rupture of membranes

• Published in: International journal of gynecology and obstetrics Vol. 90; no. 1; pp. 16 - 20
• Main Authors: Borna, S., Borna, H., Daneshbodie, B.
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 01.07.2005; Elsevier Science
• Subjects: Adult; Ascorbic Acid - administration & dosage; Biological and medical sciences; Chorioamnionitis - prevention & control; Delivery. Postpartum. Lactation; Dietary Supplements; Diseases of mother, fetus and pregnancy; Disorders; Double-Blind Method; Female; Fetal Membranes, Premature Rupture - physiopathology; Gestational Age; Gynecology. Andrology. Obstetrics; Humans; Infant, Newborn; Latency period; Medical sciences; Pregnancy; Pregnancy Trimester, Third; Pregnancy. Fetus. Placenta; Preterm; Preterm premature rupture of membranes; Time Factors; Treatment Outcome; Vitamin C; Vitamin E; Vitamin E - administration & dosage; Preterm premature rupture of membranes; Vitamin E; Latency period; Vitamin C; Preterm; Human; Premature; Ascorbic acid; Pregnancy disorders; Gynecology; Premature rupture of membrane; E-Vitamins; Obstetrics; Latency; Prematurity; Delivery disorders; Adult; Female
• ISSN: 0020-7292; 1879-3479
• DOI: 10.1016/j.ijgo.2005.03.023

Objective: To determine whether supplementation with vitamins C and E after preterm premature rupture of membranes (PPROM) is associated with an increased latency period. Methods: In this double-blind, randomized, controlled trial, 60 women with singleton pregnancies of 26 to 34 weeks' duration and PPROM were randomly assigned to vitamin C (500 mg/day) and vitamin E (400 IU/day) or placebo until delivery. All women received 2 doses of betamethasone in the first 24 h after admission as well as broad-spectrum antibiotic prophylaxis. Results: Important demographic, as well as clinical characteristics such as number of cases of chorioamnionitis, early neonatal sepsis, and respiratory distress syndrome, were similar in the 2 groups. A statically significant difference in the mean ± S.D. number of days of latency was found between the groups (10.5 ± 5.2 days vs. 3.5 ± 4.0 days ( P = 0.03). Conclusion: Vitamins C and E supplementation of after PPROM is associated with a longer latency before delivery.