Vitamins C and E in the latency period in women with preterm premature rupture of membranes
Objective: To determine whether supplementation with vitamins C and E after preterm premature rupture of membranes (PPROM) is associated with an increased latency period. Methods: In this double-blind, randomized, controlled trial, 60 women with singleton pregnancies of 26 to 34 weeks' duration...
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Published in | International journal of gynecology and obstetrics Vol. 90; no. 1; pp. 16 - 20 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
Shannon
Elsevier Ireland Ltd
01.07.2005
Elsevier Science |
Subjects | |
Online Access | Get full text |
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Summary: | Objective: To determine whether supplementation with vitamins C and E after preterm premature rupture of membranes (PPROM) is associated with an increased latency period.
Methods: In this double-blind, randomized, controlled trial, 60 women with singleton pregnancies of 26 to 34 weeks' duration and PPROM were randomly assigned to vitamin C (500 mg/day) and vitamin E (400 IU/day) or placebo until delivery. All women received 2 doses of betamethasone in the first 24 h after admission as well as broad-spectrum antibiotic prophylaxis.
Results: Important demographic, as well as clinical characteristics such as number of cases of chorioamnionitis, early neonatal sepsis, and respiratory distress syndrome, were similar in the 2 groups. A statically significant difference in the mean
±
S.D. number of days of latency was found between the groups (10.5
±
5.2 days vs. 3.5
±
4.0 days (
P
=
0.03).
Conclusion: Vitamins C and E supplementation of after PPROM is associated with a longer latency before delivery. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-News-1 ObjectType-Feature-3 content type line 23 |
ISSN: | 0020-7292 1879-3479 |
DOI: | 10.1016/j.ijgo.2005.03.023 |