Numerical studies of blood flow in healthy, stenosed, and stented carotid arteries

• Published in: International journal for numerical methods in fluids Vol. 61; no. 4; pp. 453 - 472
• Main Authors: Gay, Mickaël, Zhang, Lucy T.
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 10.10.2009; Wiley
• Subjects: Arteries; Biological and medical sciences; Biomechanics. Biorheology; Blood and lymphatic vessels; Blood flow; Cardiology. Vascular system; Carotid arteries; carotid artery; Computational methods in fluid dynamics; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous; Exact sciences and technology; Fluid dynamics; Fundamental and applied biological sciences. Psychology; Fundamental areas of phenomenology (including applications); Immersed Finite Element Method; Mathematical models; Medical sciences; Numerical analysis; oscillatory shear index; Physics; Position (location); Quantitative analysis; residence time; stenosis; stent; Surgical implants; Tissues, organs and organisms biophysics; wall shear stress; Geometrical shape; Immersed finite element method; Computational fluid dynamics; oscillatory shear index; Stenosis; Cardiovascular disease; Modeling; Stent; Artery; Blood flow; Finite element method; Carotid; wall shear stress; Shear stress; Numerical simulation; Circulatory system; Hemodynamics; residence time; carotid artery
• ISSN: 0271-2091; 1097-0363; 1097-0363
• DOI: 10.1002/fld.1966

Numerical analysis of pulsatile blood flow in healthy, stenosed, and stented carotid arteries is performed with the aim of identifying hemodynamic factors in the initiation, growth, and the potential of leading to severe occlusions of a diseased artery. The Immersed Finite Element Method is adopted for this study to conveniently incorporate various geometrical shapes of arteries without remeshing. Our computational results provide detailed quantitative analysis on the blood flow pattern, wall shear stress, particle residence time, and oscillatory shear index. The analysis of these parameters leads to a better understanding of blood clot formation and its localization in a stenosed and a stented carotid artery. A healthy artery is also studied to establish a baseline comparison. This analysis will assist in developing treatments for diseased arteries and novel stent designs to reduce restenosis. Copyright © 2008 John Wiley & Sons, Ltd.