Calcium Ions Do Accelerate the DNA Binding of New Antitumor-Active Platinum Aminophosphonate Complexes

The presence of Ca2+ has a marked effect on the reaction kinetics of platinum phosphonate complexes with d(GpG). Compounds studied are [cis‐Pt(NH3)2(bmpaa)] and [Pt(R,S‐dach)(ntmp)]. The formation of GG‐N7,N7 chelates and the release of the phosphonate ligand as observed by NMR is significantly acce...

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Published inEuropean journal of inorganic chemistry Vol. 1999; no. 10; pp. 1655 - 1657
Main Authors Bloemink, Marieke J., Diederen, Jeroen J. H., Dorenbos, Jaco P., Heetebrij, Robert J., Keppler, Bernhard K., Reedijk, Jan
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag GmbH 01.10.1999
WILEY‐VCH Verlag GmbH
Subjects
Aminophosphonate
Antitumor agents
Calcium
Platinum Complexes
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Summary:The presence of Ca2+ has a marked effect on the reaction kinetics of platinum phosphonate complexes with d(GpG). Compounds studied are [cis‐Pt(NH3)2(bmpaa)] and [Pt(R,S‐dach)(ntmp)]. The formation of GG‐N7,N7 chelates and the release of the phosphonate ligand as observed by NMR is significantly accelerated by the presence of Ca2+, which is ascribed to its interaction with the phosphato groups in the ligands.
Bibliography:ArticleID:EJIC1655
istex:E71CB1FE53C922C3252ECF0FBF57F5CAEF0D6DEC
ark:/67375/WNG-CZ19VMCR-C
ISSN:1434-1948
1099-0682
DOI:10.1002/(SICI)1099-0682(199910)1999:10<1655::AID-EJIC1655>3.0.CO;2-5