Copolymer hydrogel microspheres consisting of modified sulfate chondroitin-co-poly(N-isopropylacrylamide)

• Published in: Journal of applied polymer science Vol. 121; no. 5; pp. 2726 - 2733
• Main Authors: Reis, Adriano V., Guilherme, Marcos R., S de Almeida, Elizângela A. M., Kunita, Marcos H., Muniz, Edvani C., Rubira, Adley F., Tambourgi, Elias B.
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 05.09.2011; Wiley; Wiley Subscription Services, Inc
• Subjects: Applied sciences; Aqueous solutions; biopolymers; Cadmium sulfides; Copolymers; Droplets; emulsion polymerization; Esters; Exact sciences and technology; Hydrogels; Materials science; Microspheres; microstructure; Natural polymers; NMR; Nuclear magnetic resonance; Organic polymers; Physicochemistry of polymers; Polymers; Properties and characterization; Solution and gel properties; Starch and polysaccharides; Sulfates; synthesis; synthesis; Microsphere; microstructure; Emulsion copolymerization; Molecular structure; emulsion polymerization; Acrylamide derivative copolymer; hydrogels; Experimental study; Cadmium sulfide; Colloidal gel; Morphology; Preparation; Glycosaminoglycan; Microgel; Oside polymer; Chondroitin sulfate; Hydrogel; Methacrylate copolymer; biopolymers; Radical copolymerization; Microemulsion
• ISSN: 0021-8995; 1097-4628; 1097-4628
• DOI: 10.1002/app.33705

Modified chondroitin sulfate (π‐CdS) microspheres were synthesized by way of crosslinking‐copolymerization reaction with N‐isopropylacrylamide (NIPAAm), yielding CdS‐co‐PNIPAAm copolymer network. The incorporation of vinyl groups onto the CdS was processed with the use of glycidyl methacrylate (GMA) in an aqueous solution of pH 3.5 under stirring speed of 800 rpm at 50°C. 13C NMR and 1H NMR spectra of CdS treated with the GMA indicated the formation of 3‐methacryloyl‐1‐glyceryl ester of π‐CdS and 3‐methacryloyl‐2‐glyceryl ester of π‐CdS that are the reaction products resultant of an epoxide ring‐opening mechanism via. The synthesis of microspheres was performed via radical reaction of the vinyl groups at the π‐CdS with vinyl groups at the NIPAAm in a water−benzyl alcohol microemulsion. The formation of spherical structures is the result of the polymerization‐crosslinking reaction of the π‐CdS with the NIPAAm monomers at the droplets of water, in view that both reactants have hydrophilic characteristics at the temperature at which the reaction was processed. The pure CdS hydrogel microspheres showed a slightly cracked structure with a lower diameter range while the CdS‐co‐PNIPAAm hydrogel microspheres showed a flat and tight structure with a more regular mass distribution. © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2011