Reduced Platelet Function and Role of Drugs in Acute Gastrointestinal Bleeding

:  Gastrointestinal (GI) bleeding may be caused by a constitutive bleeding disposition or drug‐induced inhibition of hemostasis. Platelet function in patients with ongoing GI bleeding is unknown. The aim of this study was to investigate platelet function in patients with acute GI bleeding. Patients...

Full description

Saved in:
Bibliographic Details
Published inBasic & clinical pharmacology & toxicology Vol. 108; no. 3; pp. 194 - 201
Main Authors Kringen, Marianne K., Narum, Sigrid, Lygren, Idar, Seljeflot, Ingebjørg, Sandset, Per‐Morten, Trøseid, Anne‐Marie S., Johansen, Per W., Brørs, Odd, Holthe, Mette R.
Format Journal Article
LanguageEnglish
Published Oxford, UK Blackwell Publishing Ltd 01.03.2011
Blackwell
Subjects
Online AccessGet full text

Cover

Loading…
More Information
Summary::  Gastrointestinal (GI) bleeding may be caused by a constitutive bleeding disposition or drug‐induced inhibition of hemostasis. Platelet function in patients with ongoing GI bleeding is unknown. The aim of this study was to investigate platelet function in patients with acute GI bleeding. Patients (n = 35) presenting with acute GI bleeding (hematemesis or melena) were recruited. For comparison, 13 patients treated with aspirin and 11 patients treated with clopidogrel without GI bleeding and 27 healthy controls were studied. Platelet function was measured by whole‐blood aggregation and flow cytometry. Coagulation function was measured with calibrated automated thrombography. Platelet aggregation and P‐selectin expression were significantly lower after arachidonic acid stimulation in GI bleeding patients than in healthy subjects (p ≤ 0.05). Collagen‐induced P‐selectin expression was significantly reduced in patients using anti‐platelet drugs (p = 0.02) and in many patients not using anti‐platelet drugs. Thrombin generation, measured by calibrated automated thrombography, was only reduced in patients on warfarin treatment. In conclusion, platelet function is reduced in acute GI bleeding patients and a considerable proportion appears to be related to drug use.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ObjectType-Article-2
ObjectType-Feature-1
ISSN:1742-7835
1742-7843
DOI:10.1111/j.1742-7843.2010.00643.x