Prenatal diagnosis of a satellited non-acrocentric chromosome derived from a maternal translocation (10;13)(p13;p12) and review of literature

• Published in: Prenatal diagnosis Vol. 19; no. 3; pp. 282 - 286
• Main Authors: Faivre, L., Morichon-Delvallez, N., Viot, G., Larget-Piet, A., Narcy, F., Turleau, C., Pinson, M. P., Dumez, Y., Munnich, A., Vekemans, M.
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 01.03.1999; Wiley
• Subjects: Adult; Biological and medical sciences; Centromere; Chromosomes, Human, Pair 10; Chromosomes, Human, Pair 13; DNA, Satellite; Female; Genetic Counseling; genetic counselling; Gynecology. Andrology. Obstetrics; Humans; Karyotyping; Management. Prenatal diagnosis; Medical sciences; Pedigree; Practice Guidelines as Topic; Pregnancy. Fetus. Placenta; Prenatal Diagnosis; satellited non-acrocentric chromosome; Translocation, Genetic; Case study; Human; Prenatal; Translocation; Phenotype; Genetic counseling; Satellite chromosome; Fetus; Diagnosis; Genetic determinism; Bibliographic review
• ISSN: 0197-3851; 1097-0223
• DOI: 10.1002/(SICI)1097-0223(199903)19:3<282::AID-PD521>3.0.CO;2-8

We identified a familial balanced translocation involving chromosomes 10 and 13 through the finding of a satellited 10p chromosome in a fetus. The phenotype of two unbalanced products of the translocation resulting in pure monosomy 10p13 and trisomy 10p13 is described. This familial case and two of our unreported cases are discussed in the light of other prenatal observations with satellited non‐acrocentric chromosomes reported in the literature. Copyright © 1999 John Wiley & Sons, Ltd.