External validation of pharmacokinetic and pharmacodynamic models of microemulsion and long‐chain triglyceride emulsion propofol in beagle dogs
Lee, S.‐H., Park, H.‐W., Kim, M.‐J., Noh, M.‐H., Yoon, H.‐S., Choi, B.‐M., Lee, E.‐K., Noh, G.‐J. External validation of pharmacokinetic and pharmacodynamic models of microemulsion and long‐chain triglyceride emulsion propofol in beagle dogs. J. vet. Pharmacol. Therap. 35, 329–341. This study aimed...
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Published in | Journal of veterinary pharmacology and therapeutics Vol. 35; no. 4; pp. 329 - 341 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Oxford, UK
Blackwell Publishing Ltd
01.08.2012
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Subjects | |
Online Access | Get full text |
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Summary: | Lee, S.‐H., Park, H.‐W., Kim, M.‐J., Noh, M.‐H., Yoon, H.‐S., Choi, B.‐M., Lee, E.‐K., Noh, G.‐J. External validation of pharmacokinetic and pharmacodynamic models of microemulsion and long‐chain triglyceride emulsion propofol in beagle dogs. J. vet. Pharmacol. Therap. 35, 329–341. This study aimed at assessing the predictive performance of a target‐controlled infusion (TCI) system, which incorporates canine PK–PD models for microemulsion and long‐chain triglyceride emulsion (LCT) propofol and at investigating time independency of propofol effect on the observed electroencephalographic approximate entropy (ApEn) in TCI. Using a crossover design with a 7‐day washout period, 28 healthy beagle dogs were randomized to receive TCI of both formulations in a stepwise or constant manner. Plasma propofol concentrations and ApEn were measured at preset intervals. Pooled biases, inaccuracies, divergences, and wobbles in pharmacokinetic and pharmacodynamic predictions were 2.1% (95% CI: −0.8 to 4.9), 18.1% (15.6–20.5), 1.9%/h, 7.3% (5.4–9.3), and −0.5% (−2.6 to 1.6), 8.7% (7.3–10.1), 2.5%/h, 6.0% (4.1–7.2) for microemulsion propofol, and −9.3% (−11.6 to −6.9), 20.1% (18.2–22.0), 5.1%/h, 7.6% (6.1–9.1) and 5.6% (4.1–7.1), 8.0% (6.9–9.3), 4.7%/h, 4.1% (3.1–5.1) for LCT propofol. Observed ApEn values over time were statistically not different across all time points in a TCI with constant manner. Canine PK–PD model of microemulsion propofol showed good predictive performances. Propofol effect (ApEn) was time independent as long as time is allowed for equilibration. |
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Bibliography: | http://dx.doi.org/10.1111/j.1365-2885.2011.01321.x istex:57E30614A3212E9721FBA51D5D0EC71CC0EBB141 ark:/67375/WNG-LGVJLPXW-J ArticleID:JVP1321 Soo‐Han Lee and Han‐Wool Park contributed equally to this work. ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-News-1 ObjectType-Feature-3 content type line 23 |
ISSN: | 0140-7783 1365-2885 |
DOI: | 10.1111/j.1365-2885.2011.01321.x |