Pharmacokinetics and preliminary safety evaluation of azithromycin in adult horses
Leclere, M., Magdesian, K. G., Cole, C. A., Szabo, N. J., Ruby, R. E., Rhodes, D. M., Edman, J., Vale, A., Wilson, W. D., Tell, L. A. Pharmacokinetics and preliminary safety evaluation of azithromycin in adult horses. J. vet. Pharmacol. Therap. 35, 541–549. Azithromycin is widely used in foals but h...
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Published in | Journal of veterinary pharmacology and therapeutics Vol. 35; no. 6; pp. 541 - 549 |
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Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Oxford, UK
Blackwell Publishing Ltd
01.12.2012
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Subjects | |
Online Access | Get full text |
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Summary: | Leclere, M., Magdesian, K. G., Cole, C. A., Szabo, N. J., Ruby, R. E., Rhodes, D. M., Edman, J., Vale, A., Wilson, W. D., Tell, L. A. Pharmacokinetics and preliminary safety evaluation of azithromycin in adult horses. J. vet. Pharmacol. Therap. 35, 541–549. Azithromycin is widely used in foals but has not been studied in adult horses. The goals of this study were to determine the pharmacokinetic profile and to make a preliminary assessment of the safety of azithromycin in adult horses. Azithromycin was administered intravenously (5 mg/kg) and intragastrically (10 mg/kg) to six healthy mares in a crossover design. Serial plasma samples, blood neutrophils, and pulmonary macrophages were collected for the measurement of azithromycin concentrations. Azithromycin was also administered orally (10 mg/kg) once a day for 5 days to five healthy mares for preliminary evaluation of safety in adult horses. The bioavailability of azithromycin following intragastric administration was 45 ± 12%. Concentrations within peripheral neutrophils and bronchoalveolar macrophages were several fold higher than that of plasma. Mild decreases in appetite (n = 3) and alterations in fecal consistency (n = 3) were noted following repeated oral administration. The pharmacokinetic profiles of azithromycin in adult horses, especially the slow elimination rate and intraneutrophil and intrapulmonary macrophage accumulation, demonstrate that it is conducive to use in this age group. Because of the gastrointestinal alterations noted, further studies are warranted before azithromycin can be recommended for use in adult horses. |
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Bibliography: | http://dx.doi.org/10.1111/j.1365-2885.2011.01351.x istex:D7073DAD57207EB0B3A1449CA35CD39316D7C6C2 ArticleID:JVP1351 ark:/67375/WNG-R9BKVWN6-Z Piedmont Pharmaceuticals, 204 Muirs Chapel Rd., Greensboro, NC 27410, USA. Massey University, Tennent Drive, Palmerston North 4474, New Zealand. Present addresses: Department of Clinical Sciences, School of Veterinary Medicine, Université de Montréal, Montréal, QC, Canada. Dubai Equine Hospital, PO Box 9373, Dubai, UAE. |
ISSN: | 0140-7783 1365-2885 |
DOI: | 10.1111/j.1365-2885.2011.01351.x |