Properties of a bovine collagen type I membrane for guided bone regeneration applications

Dental implant treatment requires an available bone volume in the implantation site to ensure the implant’s mechanical stability. When the bone volume is insufficient, one must resort to surgical means such as guided bone regeneration (GBR). In GBR surgery, bone grafts and membranes are used. The ob...

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Bibliographic Details
Published ine-Polymers Vol. 21; no. 1; pp. 210 - 221
Main Authors Brum, Igor S., Elias, Carlos N., de Carvalho, Jorge J., Pires, Jorge L. S., Pereira, Mario J. S., de Biasi, Ronaldo S.
Format Journal Article
LanguageEnglish
Published Berlin De Gruyter 01.03.2021
Walter de Gruyter GmbH
Subjects
Biocompatibility
biomaterials
Biomedical materials
bone regeneration
Collagen
Cytotoxicity
Dental implants
Dental materials
In vivo methods and tests
Materials science
membrane
Membranes
Morphology
Polymers
Regeneration (physiology)
Rodents
Stability
Stitches
Substitute bone
Surgery
Surgical implants
Toxicity testing
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Summary:Dental implant treatment requires an available bone volume in the implantation site to ensure the implant’s mechanical stability. When the bone volume is insufficient, one must resort to surgical means such as guided bone regeneration (GBR). In GBR surgery, bone grafts and membranes are used. The objective of this work is to manufacture and characterize the and properties of resorbable collagen type I membranes (Green Membrane ) for GBR. Membrane surface morphology was characterized by SEM and roughness was measured using an interferometric noncontact 3D system. skin sensitization and toxicity tests have been performed on Wistar rats. Bone defects were prepared in 24 adult male rats, filled with biomaterials (Blue Bone and Bio Oss ) and covered with collagen membranes to maintain the mechanical stability of the site for bone regeneration. The incisions were closed with simple stitches; and 60 days after the surgery, the animals were euthanized. Results showed that the analyzed membrane was homogeneous, with collagen fiber webs and open pores. It had no sign of cytotoxicity and the cells at the insertion site showed no bone morphological changes. There was no tissue reaction and no statistical difference between Blue Bone and Bio Oss groups. The proposed membrane has no cytotoxicity and displays a biocompatibility profile that makes it suitable for GBR.
ISSN:1618-7229
2197-4586
1618-7229
DOI:10.1515/epoly-2021-0021