Assessing the effect of different shapes of glyco-gold nanoparticles on bacterial adhesion and infections

Achieving selective and sensitive carbohydrate-protein interactions (CPIs) using nanotechnology is an intriguing area of research. Here we demonstrate that the different shapes of gold nanoparticles (AuNPs) functionalized with monosaccharides tune the bacterial aggregations. The mechanism of aggrega...

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Bibliographic Details
Published inChemical communications (Cambridge, England) Vol. 51; no. 86; pp. 15669 - 15672
Main Authors Chaudhary, Preeti Madhukar, Sangabathuni, Sivakoti, Murthy, Raghavendra Vasudeva, Paul, Ajay, Thulasiram, Hirekodathakallu V., Kikkeri, Raghavendra
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 07.11.2015
Subjects
Adhesion tests
Agglomeration
Bacteria
Bacterial Adhesion - drug effects
Binding
Carbohydrates
Chemistry
Chemistry, Multidisciplinary
Escherichia coli - drug effects
Escherichia coli - physiology
Escherichia coli Infections - prevention & control
Galactose - chemistry
Galactose - pharmacology
Gold
Gold - chemistry
Gold - pharmacology
HeLa Cells
Humans
Mannose - chemistry
Mannose - pharmacology
Metal Nanoparticles - chemistry
Metal Nanoparticles - ultrastructure
Microscopy, Electrochemical, Scanning
Nanoparticles
Nanotechnology
Physical Sciences
Science & Technology
DC-SIGN
NANOCRYSTALS
GROWTH
NANORODS
NANODOTS
SURFACE-PLASMON RESONANCE
PROBES
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Summary:Achieving selective and sensitive carbohydrate-protein interactions (CPIs) using nanotechnology is an intriguing area of research. Here we demonstrate that the different shapes of gold nanoparticles (AuNPs) functionalized with monosaccharides tune the bacterial aggregations. The mechanism of aggregation revealed that the large number of surface interactions of rod shaped mannose-AuNPs with E. coli ORN 178 compared with spherical and star-shaped AuNPs exhibited higher avidity and sensitivity. Moreover, such sensitive binding can be used for effective inhibition of bacterial infection of cells.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1359-7345
1364-548X
DOI:10.1039/c5cc05238f