Thymolipoma: clues to pathogenesis revealed by cytogenetics

Abstract The pathogenesis of thymolipoma is controversial and unclear despite numerous reports. A case report of thymolipoma with cytogenetic analysis is herein presented. The lesion demonstrated a translocation involving the HMGA2 gene on chromosome 12q15, which is seen in two thirds of solitary li...

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Bibliographic Details
Published inAnnals of diagnostic pathology Vol. 13; no. 3; pp. 185 - 188
Main Authors Hudacko, Rachel, MD, Aviv, Hana, PhD, Langenfeld, John, MD, Fyfe, Billie, MD
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.06.2009
Subjects
Adult
Chromosome Aberrations
Female
HMGA2 gene
HMGA2 Protein - genetics
Humans
Lipoma
Lipoma - genetics
Lipoma - pathology
Mediastinal Neoplasms - genetics
Mediastinal Neoplasms - pathology
Pathology
Thymolipoma
Thymus
Thymus Neoplasms - genetics
Thymus Neoplasms - pathology
Translocation, Genetic
HMGA2 gene
Thymolipoma
Lipoma
Thymus
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Summary:Abstract The pathogenesis of thymolipoma is controversial and unclear despite numerous reports. A case report of thymolipoma with cytogenetic analysis is herein presented. The lesion demonstrated a translocation involving the HMGA2 gene on chromosome 12q15, which is seen in two thirds of solitary lipomas. This finding supports the theory that this case of thymolipoma is a neoplasm of thymic fat.
Bibliography:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
ObjectType-Feature-4
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ObjectType-Report-1
ObjectType-Article-3
ISSN:1092-9134
1532-8198
DOI:10.1016/j.anndiagpath.2008.02.006