Glucagon-like peptide-1 7-36 amide and peptide YY have additive inhibitory effect on gastric acid secretion in man

• Published in: Scandinavian journal of gastroenterology Vol. 32; no. 6; p. 552
• Main Authors: Wettergren, A, Maina, P, Boesby, S, Holst, J J
• Format: Journal Article
• Language: English
• Published: England 1997
• Subjects: Adult; Drug Interactions; Female; Gastric Acid - metabolism; Gastrointestinal Hormones - administration & dosage; Gastrointestinal Hormones - pharmacology; Gastrointestinal Hormones - physiology; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Humans; Infusions, Intravenous; Male; Middle Aged; Neurotransmitter Agents - administration & dosage; Neurotransmitter Agents - pharmacology; Neurotransmitter Agents - physiology; Pentagastrin; Peptide Fragments - administration & dosage; Peptide Fragments - pharmacology; Peptide Fragments - physiology; Peptide YY; Peptides - administration & dosage; Peptides - pharmacology; Peptides - physiology
• ISSN: 0036-5521; 1502-7708
• DOI: 10.3109/00365529709025098

Glucagon-like peptide-1 7-36 amide (GLP-1) and peptide YY (PYY) are colocalized in the L-cell of the ileal mucosa, and both peptides may function as enterogastrone hormones. However, it is not known whether they interact with regard to the effect on acid secretion. The effect of intravenous infusion of GLP-1 and PYY, either alone or in combination, on pentagastrin-induced acid secretion in eight healthy volunteers was examined. The peptides were infused at two different rates: 0.25 pmol/kg/min (low rate) and 0.5 pmol/kg/min (high rate). Given alone, GLP-1 and PYY inhibited acid secretion by 26 +/- 5% and 18 +/- 5% (low rate) and 45 +/- 8% and 38 +/- 7% (high rate), respectively. Combined infusion resulted in an inhibition of 32 +/- 5% (low rate) and 62 +/- 7% (high rate). Both infusion rates resulted in GLP-1 and PYY plasma concentrations below or similar to postprandial levels. The present study suggests that the interaction between GLP-1 and PYY in man is of the additive type. The results indicate that GLP-1 and PYY have an important role in the physiologic control of gastric acid secretion.