Effectiveness and Immunogenicity of the MMR Vaccine Against SARS-CoV-2 Among Healthcare Workers

• Published in: Viruses Vol. 17; no. 2; p. 215
• Main Authors: Seok, Hyeri, Bae, Joon-Yong, Kim, Jooyun, Choi, Won Suk, Park, Heedo, Lee, Jungmin, Lee, Sohyun, Kim, Chulwoo, Park, Man-Seong, Park, Dae Won
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.02.2025; MDPI
• Subjects: Adult; Antibodies; Antibodies, Neutralizing - blood; Antibodies, Neutralizing - immunology; Antibodies, Viral - blood; Antibodies, Viral - immunology; Brief Report; Coronaviruses; COVID-19; COVID-19 - immunology; COVID-19 - prevention & control; COVID-19 vaccines; Effectiveness; Epidemics; Female; Health care; Health Personnel - statistics & numerical data; Humans; Hypotheses; Immune status; Immunity (Disease); Immunogenicity; Immunogenicity, Vaccine; Immunoglobulin G; Immunoglobulin G - blood; Infections; Male; Measles; Measles-Mumps-Rubella Vaccine - administration & dosage; Measles-Mumps-Rubella Vaccine - immunology; measles–mumps–rubella vaccine; Medical personnel; Middle Aged; Mumps; Performance evaluation; Rubella; SARS-CoV-2; SARS-CoV-2 - immunology; Severe acute respiratory syndrome coronavirus 2; vaccine effectiveness; Vaccine Efficacy; vaccine immunogenicity; Vaccines; Young Adult; COVID-19; vaccine effectiveness; SARS-CoV-2; vaccine immunogenicity; measles–mumps–rubella vaccine
• ISSN: 1999-4915; 1999-4915
• DOI: 10.3390/v17020215

The purpose of this study was to evaluate the effectiveness and immunogenicity of the measles–mumps–rubella (MMR) vaccine against SARS-CoV-2 in healthcare workers at one medical institution. The effectiveness of the MMR vaccine against SARS-CoV-2 was evaluated in overall healthcare workers (HCWs). In addition, neutralizing antibodies to SARS-CoV-2 were measured according to the subjects’ measles immunity status with serum samples collected before the coronavirus disease 2019 pandemic period. The effectiveness of the MMR vaccine for SARS-CoV-2 in all HCWs and measles IgG-positive subjects was 34% (adjusted odds ratio [aOR] = 1.20, 95% confidence interval [CI] = 0.53–2.70) and 34% (aOR = 0.66, CI = 0.38–18.4), respectively. The neutralizing antibody levels for SARS-CoV-2 were low in all groups regardless of the measles immune status. The MMR vaccine alone may not provide sufficient protection against SARS-CoV-2.