Bone marrow adipose tissue is associated with fracture history in anorexia nervosa

• Published in: Osteoporosis international Vol. 33; no. 12; pp. 2619 - 2627
• Main Authors: Dang, T., Faje, A. T., Meenaghan, E., Bredella, M. A., Bouxsein, M. L., Klibanski, A., Fazeli, P. K.
• Format: Journal Article
• Language: English
• Published: London Springer London 01.12.2022; Springer Nature B.V
• Subjects: Absorptiometry, Photon; Adipose tissue; Adipose Tissue - diagnostic imaging; Anorexia; Anorexia Nervosa - complications; Body fat; Body weight; Bone Density - physiology; Bone Marrow; Bone mineral density; Computed tomography; Cross-Sectional Studies; Dual energy X-ray absorptiometry; Eating disorders; Endocrinology; Female; Femur; Fractures; Fractures, Bone; Humans; Medicine; Medicine & Public Health; Original Article; Orthopedics; Osteoporosis; Prospective Studies; Rheumatology; Bone marrow adipose tissue; Fracture; Anorexia nervosa
• ISSN: 0937-941X; 1433-2965
• DOI: 10.1007/s00198-022-06527-3

Summary Although bone mineral density (BMD) is decreased and fracture risk increased in anorexia nervosa, BMD does not predict fracture history in this disorder. We assessed BMD, bone microarchitecture, and bone marrow adipose tissue (BMAT) in women with anorexia nervosa and found that only BMAT was associated with fracture history. Introduction Anorexia nervosa (AN) is a psychiatric disorder characterized by low body weight, low BMD, and increased risk of fracture. Although BMD is reduced and fracture risk elevated, BMD as assessed by DXA does not distinguish between individuals with versus those without prior history of fracture in AN. Despite having decreased peripheral adipose tissue stores, individuals with AN have enhanced bone marrow adipose tissue (BMAT), which is inversely associated with BMD. Whether increased BMAT is associated with fracture in AN is not known. Methods We conducted a cross-sectional study in 62 premenopausal women, including 34 with AN and 28 normal-weight women of similar age. Fracture history was collected during patient interviews and BMD measured by DXA, BMAT by 1 H-MRS, and parameters of bone microarchitecture by HR-pQCT. Results Sixteen women (47.1%) with AN reported prior history of fracture compared to 11 normal-weight women (39.3%, p  = 0.54). In the entire group and also the subset of women with AN, there were no significant differences in BMD or parameters of bone microarchitecture in women with prior fracture versus those without. In contrast, women with AN with prior fracture had greater BMAT at the spine and femur compared to those without ( p  = 0.01 for both). Conclusion In contrast to BMD and parameters of bone microarchitecture, BMAT is able to distinguish between women with AN with prior fracture compared to those without. Prospective studies will be necessary to understand BMAT’s potential pathophysiologic role in the increased fracture risk in AN.