Mechanisms for incorporation of glycerol-derived precursors into polyketide metabolites

Several polyketide secondary metabolites are shown by feeding experiments to incorporate glycerol-derived 3-carbon starter units, 2-carbon extender units, or 3-carbon branches into their hydrocarbon chains. In recent years, genetic studies have begun to elucidate the mechanisms by which this occurs....

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Bibliographic Details
Published inJournal of industrial microbiology & biotechnology Vol. 33; no. 2; pp. 105 - 120
Main Authors WALTON, Laura J, CORRE, Christophe, CHALLIS, Gregory L
Format Journal Article
LanguageEnglish
Published Heidelberg Springer 01.02.2006
Springer Nature B.V
Subjects
Bacteria
Biological and medical sciences
Biotechnology
Carbon
Fundamental and applied biological sciences. Psychology
Glycerol
Glycerol - metabolism
Incorporation
Macrolides - chemistry
Macrolides - metabolism
Metabolites
Polyketide Synthases
Secondary metabolites
Streptomyces - enzymology
Streptomyces - metabolism
Polyketide
Incorporation
Metabolite
Glycerol
FkbH
Precursor
Mechanism
Lactyl-ACP
Methoxymalonyl- ACP
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Summary:Several polyketide secondary metabolites are shown by feeding experiments to incorporate glycerol-derived 3-carbon starter units, 2-carbon extender units, or 3-carbon branches into their hydrocarbon chains. In recent years, genetic studies have begun to elucidate the mechanisms by which this occurs. In this article we review the incorporation of glycerol-derived precursors into polyketides and propose new mechanisms for the incorporation processes.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:1367-5435
1476-5535
DOI:10.1007/s10295-005-0026-7