A human gastric cancer cell line possesses a functional receptor for gastrin-releasing peptide

• Published in: Cancer investigation Vol. 16; no. 1; p. 12
• Main Authors: Bold, R J, Kim, H J, Ishizuka, J, Townsend, Jr, C M, Thompson, J C
• Format: Journal Article
• Language: English
• Published: England 1998
• Subjects: Adenocarcinoma - pathology; Bombesin - metabolism; Calcium - metabolism; Cross-Linking Reagents; DNA, Complementary - genetics; Gene Expression; Humans; Receptors, Bombesin - metabolism; RNA, Messenger - genetics; Stomach Neoplasms - pathology; Tumor Cells, Cultured - pathology

Bombesin (BBS) exhibits diverse biological functions including those of neurotransmitter, regulator of gastrointestinal hormone release, and mitogen. Gastrin-releasing peptide (GRP, the mammalian equivalent of BBS) is found in mucosal cells of the gastric fundus and antrum. We determined whether a h...